Biochemistry
9th Edition
ISBN: 9781319114671
Author: Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher: W. H. Freeman
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What properties of glucokinase allow it to phosphorylate glucose in the liver when the blood glucose concentration is higher than normal?
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- Please explain gluconeogenesis. What is it? Where does it occur and why?arrow_forward64 An investigator is studying the mechanism of action of an insulin-sensitizing drug. The addition of the drug to cultured mouse hepatocytes is observed, and results show increased phosphorylation and inhibition of acetyl-CoA carboxylase Which of the following processes is most likely inhibited by this action of the drug? A) Fatty acid oxidation B) Fatty acid synthesis C) Glycogen synthesis D) Glycolysis E) Protein synthesisarrow_forwardGlucose 6-phosphatase deficiency is a glycogen storage disease referred to as von Gierke disease. Which of the following symptoms would you NOT expect to see in patients with this disease? (A) severe fasting hypoglycemia (B) excess adipose triglyceride storage and low circulating levels of fatty acids (C) hyperammonemia (D) liver enlargement resulting from excess liver glycogen storage (E) lactic acidosis (F) goutarrow_forward
- Describe two different ways in which glucose oxidase is regulated.arrow_forwardIn the fasted state, FADH2 and NADH for oxidative phosphorylation are mainly provided by fatty acid oxidation. Explain how fatty acids are mobilised from adipose tissue by the action of glucagon.arrow_forwardIf protein phosphatase 1 (PP1) is inhibited does Glycogen Synthase Kinase 3 become more active?arrow_forward
- How do levels of fructose-2,6-bisphosphate impact activity of phosphofructokinase and fructose-1,6-bisphosphatase?arrow_forwardWhat kind of protein is lactase, the biomolecule that speeds up the breakdown of lactose?arrow_forwardWhat is the quaternary structure of glycogen phosphorylase? How would you characterize the allosteric effects of its small molecule substrate? (one word) What allosteric model (mechanism) that you have learned does it seem to follow? (one acronym)arrow_forward
- Explain why people with a hereditary deficiency of carnitine acyltransferase II have muscle weakness. Why are the symptoms more severe during fasting? (Keep your answer to at least a paragraph)arrow_forwardIs GAPDH only a glycolytic enzyme? What are the other physiological functions of GAPDH?arrow_forwardHow is Glucose transported into the cell? What is the difference between GLUT2 and GLUT4?arrow_forward
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