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What properties are gained during tumor progression that contribute to malignant behavior and metastasis?
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- What are the normal functions of the BRCA1 tumor suppressor gene?How does the epithelial-to-mesenchymal transition (EMT) contribute to tumorigenesis and disease progression?Tissues and differentiation: a) Explain what is meant by determination and differentiation b) Explain the difference between an oncogene and a tumor suppressor gene and describe how they are involved in the development of cancer
- When some cancer cells produce growth factors that stimulate their own division leading to continuous self- stimulation for cell division it is referred to as a) TNF tumor necrosis factor b) AGS autocrine growth stimulationWhat is the role of the microenvironment in cancer development and progression?What are the key steps of transformation, tumorigenesis and metastasis on a cellular and tissue level.