What is/are the relay molecules for the epinephrine receptors? What is/are the relay molecules for the EGF receptors?

7 of 41 Which statement relating to endocrine signaling is false? O Histamine is a paracrine O Hormonal signals enter the bloodstream, so hormones influence all cells with which they come in contact Hormones are released to the extracellular fluid and then diffuse into the bloodstream. O Some endocrine cells exist as single cells within a tissue. O Hormones, paracrines, and autocrines bind to receptors

1. Researchers incubated J3’s in the absence of Unknown Factor X. Upon the addition of a membrane-permeant cGMP agonist (a cGMP agonist able to penetrate into the J3’s) you would expect to see STIMULATION/INHIBITION (highlight one) of the J3 activation pathway.2. Researchers incubated J3’s in the presence of Unknown Factor X, but with the addition of a membrane-permeant CYP antagonist. In this case, you would expect to see STIMULATION/INHIBITION (highlight one) of the J3 activation pathway.

Afatinib is an effective first-line treatment for patients with EGFR-mutant NSCLC. Research groups designed and synthesized afatinib analogs to increase the inhibitory effect against EGFR and VEGFR2/KDR kinases. Meo. OMe Br HN HN OMe Afatinib Compound I Compound II The researchers run a series of tests to explore the kinase inhibitory activity of Afatinib and Compound I with EGFR. They found the IC50 of Compound I is 3.6 nM and that of Afatinib is 1.6nM. a. Please briefly explain the effectiveness of Compound I compare to Afatinib based on the information given