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- You work for a pharmaceutical company where you are assigned the task of creating new drug therapies to treat thyroid disorders such as hyperthyroidism (high levels of T3 and T4) and hypothyroidism (low levels of T3 and T4). Your team has designed a few drugs, and your job is to identify which drug(s) would be successful in treating thyroid disorders based on your knowledge of thyroid hormone synthesis. Below is the list of drugs your team designed (all of these are hypothetical drugs). Please identify the drug(s) that would be successful in treating hypothyroidism, and explain why and how they would be successful. Aldosine: A drug that inhibits production of angiotensinogen from the liver Aldoramine: A drug that inhibits sodium/iodine cotransporter Thyromine: A drug that stimulates thyroglobulin production Peroxidine: A drug that inhibits thyroid peroxidase from functioning Cimigine: A drug that inhibits potassium/iodine cotransporter Iodimine: A drug that inhibits iodinase from…1) What is the full name of the following molecule? 2) Briefly explain the functions of this molecule. 3) Name the HORMONES that control the levels of this molecule. top H H HO OH H 0 CH₂OHLook at the structures of the three female sex hormones shown on page 867. Identify the type of functional group change that interconverts estradiol and estrone. To which class of chemical reactions does this change belong?
- Which of the following is NOT generally considered to be a function of oxytocin? 1) uterine contractions during labor 2) milk 'let down' for breast feeding 3) enhancement of insulin sensitivity in smooth muscle 4) enhancement of mother-infant bonding no references, just homeworkWhich of the following is not correct about phosphorylation by IRS on serine residue? a) Target tissues fail to respond to circulating insulin b) It increases insulin levels c) It is an inhibitory phosphorylation d) It is molecular mechanism for insulin resistanceHydrocortisone is an over-the-counter ointment commonly used to treat eczema. Eczema is a skin condition where a patch of skin becomes irritated and inflamed. It is estimated that approximately 15% of Canadians are affected by eczema at some point in their lives. The active ingredient in hydrocortisone cream is the hormone cortisol. Which of the following statements describes why hydrocortisone is an effective treatment for eczema? Select one: a. Hydrocortisone helps to fight off the skin infection by increasing the immune response. b. Hydrocortisone helps to suppress the skin inflammation by decreasing the immune response. c. Hydrocortisone helps to suppress the skin inflammation by increasing the immune response. d. Hydrocortisone helps to fight off the skin infection by decreasing the immune response.
- Why is taking too much Valium not as dangerous as taking too much Phenobarbital?1. What are tropic hormones? 2. What are TRH and TSH? 3. Why are they referred to as tropic hormones? 4. Which cells in the thyroid help in producing T3 and T4? 5. Which trace elements is critical for the synthesis of T3 and T4? 6. Which cells in the thyroid gland produce calcitonin? 7. Which mineral is regulated by calcitonin?determine the principle involved or color reaction mechanism of each steroid. progesterone with sulphuric acid methyl testosterone with sulphuric acid prednisone with sulphuric acid androsterone with sulphuric acid
- Below are structures of several steroid hormones derived from cholesterol. Circle the steroid nucleusin each.Thyroid cancer results when the cells in the thyroid gland divide uncontrollably. Individuals who have excessive exposure to radiation may have higher chance of getting thyroid cancer. Thyroid cancer can be treated through surgery, iodine therapy, radiotherapy, and/or chemotherapy. What is the purpose of prescribing thyroxine medication for patients following the surgical removal of the thyroid gland? Select one: a. to decrease TRH and increase TSH levels b. to increase TRH and TSH levels c. to decrease TRH and TSH levels d. to increase TRH and decrease TSH levelsThyroxine is a peptide hormone, but its mechanism is different from other peptide hormones. Which of the following statements is true concerning this difference? A) It does not require a second messenger to initiate a response B) It is a steroid hormone but acts like an amino-acid based hormone C) inhibits cellular metabolism and targets all cells D) Its production is controlled by a positive feedback mechanism E) It is very specific in the cell type it targets.
