Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN: 9780134580999
Author: Elaine N. Marieb, Katja N. Hoehn
Publisher: PEARSON
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What is the likely nature of the morphogenetic substance that gives rise to alkaline phosphatase?
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- PDHC is an enzyme complex consisting of 3 different enzymes. Which of the following processes regulate the activity of PDH Complex? (multiple answers) A) Phosphorylation/Dephosphorylation of E1 B) High levels of cAMP C) Acetylation/Deacetylation of E1 D) High NADH/NAD+ ratio E) High NAD+/NADH ratioarrow_forwardAutophagy Is Required for PKA Activation and Cell Viability upon GlucoseStarvation. The functional relationship between PKA and autophagyis largely unclear. Because PKA controls cell metabolism particularly related to glucose status (21–23), we first examined the relationship between autophagy and PKA activity in the control of cellmetabolism with glucose limitation. We found that in addition toactivating autophagy, glucose starvation also induced the phosphorylation of cAMP response element-binding (p-CREB), a wellknown PKA substrate, indicative of elevated PKA activity in bothHEK293T and HCT116 cells. In contrast, disruption of autophagyby deletion of essential autophagy gene Atg7 or Atg14 abolished theincrease of p-CREB levels in the above cells (SI Appendix, Fig.S1 A, B, D, and E), suggesting that inactivation of autophagy suppresses PKA activity in response to energy shortage. Moreover, lossof Atg7 or Atg14 accelerated cell death in response to glucosestarvation (SI Appendix, Fig.…arrow_forwardWhat are the physiological processes in which caion is involvedarrow_forward
- Describe the steps of TH1 activation in 2 to 3 paragraphsarrow_forwardQ21arrow_forwardThe hydrolysis of GTP to GDP is a reversible reaction as shown below. The ΔG for the reaction is ±30.5 kJ/mol. ΔG = ± 30.5 kJ/mol GTP + H2O GDP + Pi a) Which signalling pathway in the above diagram utilizes this forward reaction? (mTOR pathway, Hippo pathway, Both pathways, or Neither pathway) b) Which protein possesses this enzymatic activity within that pathway?arrow_forward
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