Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN: 9780134580999
Author: Elaine N. Marieb, Katja N. Hoehn
Publisher: PEARSON
expand_more
expand_more
format_list_bulleted
Related questions
Concept explainers
Question
what experiemnts show Shh is the signaling molecule from the ZPA?
Expert Solution
arrow_forward
Step 1
The SHH gene provides instructions for making a protein called Sonic Hedgehog.
- This protein functions as a chemical signal that is essential for embryonic development.
- Sonic Hedgehog plays a role in cell growth, cell specialization, and the normal shaping of the body.
Signals that instruct the developing limb bud mesenchyme to form the appropriate elements along the anterior posterior axis emanate from the zone of polarizing activity (ZPA). Sonic hedgehog (Shh) protein mediates the activities of the ZPA.
Trending nowThis is a popular solution!
Step by stepSolved in 2 steps
Knowledge Booster
Learn more about
Need a deep-dive on the concept behind this application? Look no further. Learn more about this topic, biology and related others by exploring similar questions and additional content below.Similar questions
- Jhat are the two problems that a protein component of an intracellular signaling circuit must solve?arrow_forwardBriefly explain how integrin inside-out and outside-in signaling is different structurally and functionally? (hint: explain what happened to ligand binding and conformation)arrow_forwardHow could you determine whether a hormone-mediated response hasresulted from the intracellular mediator mechanism or the nuclearreceptor mechanism?arrow_forward
- What is an evolutionaryexplanatory hypothesis for thesecretion by the heart of ahormone that regulates therenal function? Which is thathormone?arrow_forwardWhat are the effects of calcium as a seconf messenger?arrow_forwardA cellular response occurs when a signal transduction pathway is activated in animals. Explain two forms of cellular responses that may arise as a result of paracrine or endocrine signaling.arrow_forward
- List two ways that GPCR signaling transduction can be turned off (go back to inactive state)arrow_forwardThe hydrolysis of GTP to GDP is a reversible reaction as shown below. The ΔG for the reaction is ±30.5 kJ/mol. ΔG = ± 30.5 kJ/mol GTP + H2O GDP + Pi a) Which signalling pathway in the above diagram utilizes this forward reaction? (mTOR pathway, Hippo pathway, Both pathways, or Neither pathway) b) Which protein possesses this enzymatic activity within that pathway?arrow_forwardSuppose that a G protein undergoes a mutation that allows the exchange of bound GTP for GDP to occur in the absence of G protein binding to a re- ceptor. How might this mutation affect signaling involving a GPCR? Which subunit of the G protein is most likely affected by the mutation?arrow_forward
arrow_back_ios
arrow_forward_ios
Recommended textbooks for you
- Human Anatomy & Physiology (11th Edition)BiologyISBN:9780134580999Author:Elaine N. Marieb, Katja N. HoehnPublisher:PEARSON
Biology 2eBiologyISBN:9781947172517Author:Matthew Douglas, Jung Choi, Mary Ann ClarkPublisher:OpenStax
Anatomy & PhysiologyBiologyISBN:9781259398629Author:McKinley, Michael P., O'loughlin, Valerie Dean, Bidle, Theresa StouterPublisher:Mcgraw Hill Education, 
Molecular Biology of the Cell (Sixth Edition)BiologyISBN:9780815344322Author:Bruce Alberts, Alexander D. Johnson, Julian Lewis, David Morgan, Martin Raff, Keith Roberts, Peter WalterPublisher:W. W. Norton & Company
Laboratory Manual For Human Anatomy & PhysiologyBiologyISBN:9781260159363Author:Martin, Terry R., Prentice-craver, CynthiaPublisher:McGraw-Hill Publishing Co.
Inquiry Into Life (16th Edition)BiologyISBN:9781260231700Author:Sylvia S. Mader, Michael WindelspechtPublisher:McGraw Hill Education
Human Anatomy & Physiology (11th Edition)
Biology
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:PEARSON
Biology 2e
Biology
ISBN:9781947172517
Author:Matthew Douglas, Jung Choi, Mary Ann Clark
Publisher:OpenStax
Anatomy & Physiology
Biology
ISBN:9781259398629
Author:McKinley, Michael P., O'loughlin, Valerie Dean, Bidle, Theresa Stouter
Publisher:Mcgraw Hill Education,
Molecular Biology of the Cell (Sixth Edition)
Biology
ISBN:9780815344322
Author:Bruce Alberts, Alexander D. Johnson, Julian Lewis, David Morgan, Martin Raff, Keith Roberts, Peter Walter
Publisher:W. W. Norton & Company
Laboratory Manual For Human Anatomy & Physiology
Biology
ISBN:9781260159363
Author:Martin, Terry R., Prentice-craver, Cynthia
Publisher:McGraw-Hill Publishing Co.
Inquiry Into Life (16th Edition)
Biology
ISBN:9781260231700
Author:Sylvia S. Mader, Michael Windelspecht
Publisher:McGraw Hill Education