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What is the E-value of the sequence, what does your E-value reflect and what’s the importance of an E-value?

Case Studies In Health Information Management

3rd Edition

ISBN:9781337676908

Author:SCHNERING

Publisher:SCHNERING

Chapter4: Revenue Management

Section: Chapter Questions

Problem 4.16.2C

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Question

What is the E-value of the sequence, what does your E-value reflect and what’s the importance of an E-value?

Expert Solution

Step 1

Bioinformatics is the branch of science that deals with the genome, gene, and protein sequences. It is a combination of computational and biology information where a large amount of biological related data can be stored by computer-based tools or databases. So that one can easily access all the information for their research. Different tools and databases come under bioinformatics like BLAST, FASTA, NCBI, Uniprot, etc.

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Using the Dynamic Programming algorithm for pairwise local alignment we covered in class, construct the dynamic programming score table for a local alignment of the following two sequences, using the following scoring parameters: match score = +5, mismatch score = -3, gap penalty = -2.: ACGTATCGCGTATA GATGCTCTCGGAAAWhat is score of the best local alignment between these two sequences? Show the alignment of these sequences. asap
a - What is Position-Specific Scoring Matrices (PSSM) and how do we obtain it? b - Construct the HMM for the following sequences where the matches are considered for the columns that don't have any gap T G A A G T T G A I A G G C A G T G G C T A G
a - What is Position-Specific Scoring Matrices (PSSM) and how do we obtain it? b - Construct the HMM for the following sequences where the matches are considered for the columns that don't have any gap T G A C А G T G A А G G T G G A G G C A G EE E E E
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For the following sequence, what is the Tm? 5'-AGCTACGATCAGGTCA-3'
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