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What is an advantage of using recombinant DNA to make proteins such as insulin, human growth hormone, or blood-clotting factors?

Human Heredity: Principles and Issues (MindTap Course List)

11th Edition

ISBN:9781305251052

Author:Michael Cummings

Publisher:Michael Cummings

Chapter1: A Perspective On Human Genetics

Section: Chapter Questions

Problem 6QP

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Concept explainers

Genomics

Genes are responsible for transmitting the characters located on the chromosomes from one individual to another across the generations. Genetics is the study of different genes that are involved in different functions. Genetics is a branch of biology that studies genes, genetic diversity, and heredity in living organisms. The genetic system consists of genetic notations, which is a system of signs and symbols. Genotype refers to the organism's genetic composition, and phenotype refers to the observable property of the organism.

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What is recombinant DNA? How can it be used to produce human proteins in bacteria?
a) Explain the difference between a genome and a transcriptome. Do all cells in an organism have the same genomes and or transcriptomes? b) Explain a method you could use to compare transcriptomes, and what you can learn from comparing transcriptomes.
what are the advantages of using recombinant dna to produce human hormones such as insulin and sormatotropin?
How can a person's muscle cells have the same exact DNA sequences as their nerve cells even though the look and perform completely different? a) The cells have different combinations of alleles. b) The cells synthesize different proteins. c) The cells have differences in their genomes. d) All of the above
What is the purpose of recombinant DNA?
Xeroderma pigmentosum is a genetic disease caused by an error in the nucleotide excision repair process that fixes damage to DNA by ultraviolet light. Studies have shown that it can result from mutations in any one of seven genes. What can you infer from this finding? A) There are seven genes that produce the same protein B) These seven genes are the most easily damaged by ultraviolet light. C) There are seven enzymes involved in the nucleotide excision repair process. D) These mutations have resulted from translocation of gene segments.
A large portion of the human genome is transposons. Collectively, they are most likely: A) an equal mix of DNA and retrotransposons B) mostly DNA transposons because they are found in DNA C) mostly retrotransposons because they copy themselves each time they move D) mostly DNA transposons because they can cut themselves out
What is the point of genome sequencing?
Herbert Boyer and Stanley Cohen pioneered the technique of DNA cloning allowing genes to be transferred from another biological species easily. Their work also gave rise to the development of different recombinant proteins with therapeutic applications like insulin and growth hormone. The former was cloned using Escherichia coli. coli in 1978. With this breakthrough, the first licensed drug produced using recombinant DNAtechnology was human insulin, developed by Genentech, licensed and marketed by Eli Lilly in 1982. Scientists were able to identify and isolate the gene fragment or the gene of interest, in this case, the gene that is responsible for producing insulin. Moreover, they were able to isolate the bacterial DNA of E. coli. The plasmid and DNA fragment were cut using a restriction enzyme. This DNA fragment was inserted into the plasmid using a DNA ligase. When the DNA fragment was then placed into the bacterial DNA, it was then introduced to the host cell (E. coli) and was then…
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