What happens to membrane potential during manipulation 4 in the attached figure (Figure 4.13 of the textbook)? 1 Efflux of Nat Nat efflux (logarithmic scale) 0 3 Recovery when K+ is restored 2 Nat efflux reduced by removal of external K 50 100 4 Efflux decreased by metabolic inhibitors, such as dinitrophenol, which block ATP synthesis 150 Time (min) 200 5 Recovery when ATP is restored " I 250 TATI 122 O Membrane potential does not change, because the Na+-K+ ATPase does not contribute to membrane potential. O Membrane potential is hyperpolarized, because the Na+-K+ ATPase is electrogenic and hyperpolarizes membrane potential when it is active. O Membrane potential is depolarized, because the Na+-K+ ATPase is electrogenic and hyperpolarizes membrane potential when it is active. 300

Biochemistry
6th Edition
ISBN:9781305577206
Author:Reginald H. Garrett, Charles M. Grisham
Publisher:Reginald H. Garrett, Charles M. Grisham
Chapter32: The Reception And Transmission Of Extracellular Information
Section: Chapter Questions
Problem 14P
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Question
What happens to membrane potential during
manipulation 4 in the attached figure (Figure 4.13
of the textbook)?
1 Efflux of Nat
Nat efflux (logarithmic scale)
0
3 Recovery when
K+ is restored
2 Nat efflux reduced
by removal of
external K
50
100
4 Efflux decreased by metabolic
inhibitors, such as dinitrophenol,
which block ATP synthesis
150
Time (min)
200
5 Recovery when
ATP is restored
"
I
250
TATI
122
O Membrane potential does not change, because the Na+-K+
ATPase does not contribute to membrane potential.
O Membrane potential is hyperpolarized, because the Na+-K+
ATPase is electrogenic and hyperpolarizes membrane potential
when it is active.
O Membrane potential is depolarized, because the Na+-K+
ATPase is electrogenic and hyperpolarizes membrane potential
when it is active.
300
Transcribed Image Text:What happens to membrane potential during manipulation 4 in the attached figure (Figure 4.13 of the textbook)? 1 Efflux of Nat Nat efflux (logarithmic scale) 0 3 Recovery when K+ is restored 2 Nat efflux reduced by removal of external K 50 100 4 Efflux decreased by metabolic inhibitors, such as dinitrophenol, which block ATP synthesis 150 Time (min) 200 5 Recovery when ATP is restored " I 250 TATI 122 O Membrane potential does not change, because the Na+-K+ ATPase does not contribute to membrane potential. O Membrane potential is hyperpolarized, because the Na+-K+ ATPase is electrogenic and hyperpolarizes membrane potential when it is active. O Membrane potential is depolarized, because the Na+-K+ ATPase is electrogenic and hyperpolarizes membrane potential when it is active. 300
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