what effect would an increase in glucose typically have on the activity of glycogen synthase
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- what is one physiological consequence that might occur if gluconeogenesis was the exact opposite of glycolysis? please helpWhy is it essential that the mechanisms that activate glycogen synthesis also deactivate glycogen phosphorylase?Patients with von Gierke’s disease (a glycogen storage disease) lack glucose-6- phosphatase activity. Two prominent symptoms of this disorder are fasting hypoglycemia and lactic acidosis. Can you explain why these symptoms occur?
- How does glucose binding to glycogen phosphorylase stimulate glycogen synthesis?In simple terms explain why gluconeogenesis is important?Glucagon is released from the pancreas in response to low blood glucose levels. It regulates the opposing pathways of glycolysis and gluconeogenesis by altering levels of fructose 2,6-bisphosphate. If glucagon causes a decrease in fructose 2,6-bisphosphate, how does this increase blood glucose levels? Explain..
- How does the hydrolysis of fructose-1,6- bisphosphate bring about the reversal of one of the physiologically irreversible steps of glycolysis?How does the role of glucose-6- phosphate in gluconeogenesis differ from that in glycolysis?Gluconeogenesis takes place during intense exercise, which seems counterintuitive. Why would an organism synthesize glucose and at the same time use glucose to generate energy?
- Name the key enzymes of gluconeogenesis. Explain how lactate is converted to glucose.Phosphoglucomutase is crucial for glycogen breakdown as well as for glycogen synthesis. Explain the role of this enzyme in each of the two processes.Glucose binds to glycogen phosphorylase and competitively inhibits the enzyme. What is the physiological advantage of this?