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- What is the importance ofKRAS gene in the development of colorectal cancer. ?According to the American Cancer Society, colon cancer screening should begin at age 50 for people at average risk. Imagine you have a family history of colon cancer. From your research, with reasons which procedures would your physician order for you and at what age ?What is the relationship between DM and development of Pancreatic Cancer? How can we prepare patients diagnosed with stage 4 Pancreatic CA for palliative care?
- How colorectal cancers develop through the accumulation of mutations in several genes ?What is the importance of inflammatory response genes in adenocarcinoma tumours in regards to bowel cancer. what are there benefits. what are there roles. provide detailed analyse wiht exmaples and evidence.What are the current diagnosis and treatments for adencarcinoma colon cancer. Give analysis and examples on we can detect the disease at the gene level. what treatment and therapies are available.
- For each of the following statements relating to Hereditary Bowel cancer, explain why they are correct or incorrect: a) b) c) d) e) Only people under the age of 20 are affected Genetic testing is of no benefit Screening by bowel endoscopy is of no benefit Each child of a man with polyposis coli has a 50% chance of being affected Everyone affected has over 100 polyps in their proximal colon.1. the wnt story:- a) Discuss the role of Wnt pathway in the normal development of epithelia within the colon – stem cells, differentiated epithelia, and shedding epithelia. b)Then discuss how this path gets altered in the familial cancer FAP – familial adenomatous polyposis? How does it get impacted in non-hereditary colon cancer? Your discussion should explain how the altered wnt path leads to hyperplastic epitheliaWhat is the multi hit approch/hypothesis to adencinocama colonrecal cancer. explain and analyse the pathways and genes
