We looked at two main groups of chemicals, one being the steroidal compounds.  What characteristics do steroidal compounds have in common in regard to a. how they are similar in chemical structure - describe the important components of the structure? b. what physical/chemical characteristics are shared by these compounds (apart from the structure)? c. What is it about their shape/chemistry that gives them physiological effects specifically in humans?

Small molecules are used as inhibitors of protein action - as drugs. They most often do this by blocking the active site within the protein. Potential drugs can be screened computationally to determine if they are strongly bound to the protein. Figure 1 shows a possible conformation of a candidate drug molecule, 4-bromo-2- carboxymethylamide-pyrrole (abbreviation: BCMAP) at the active site of a protein (abbreviation: PR). Figure 2 shows the full protein structure whilst figure 3 shows a known inhibitor of the protein at the site, overlayed with another calculated conformer of BCMAP. (a) Explain what types of interactions, both intermolecular and intramolecular, that a molecular mechanics forcefield must be able to describe in order to be able to accurately determine the geometry of BCMAP in the protein. Identify which interactions will be the most important to describe accurately. Figure 1.4-bromo-2-carboxymethylamide-pyrrole (BCMAP) (C, N, O, and Br atoms in yellow, blue, red, and…

Identify the incorrect statement regarding the polypeptide, Myoglobin. Select one: a. The interaction between Myoglobin and O2 is homotopic in nature as indicated by a Hill coefficient n = : 1 b. Myoglobin is found predominantly in muscle tissue because it facilitates oxygen diffusion. c. The majority of Myoglobin's secondary structure is composed of alpha-helices d. Myoglobin has a higher affinity for oxygen than Hemoglobin e. Myoglobin serves as an oxygen storage protein as suggested by its hyperbolic binding of 02

This question relates to morphine (shown below) and the relationships betweenchanging chemical structure and biological activity.  Intermolecular interactions play a key role in the binding of morphine to its receptor. Statethe types of interaction that may occur and discuss the key structural features of morphineassociated with these interactions.(b) With respect to the parent compound, explain in detail how modifying the rings shownas A, B, C, D and E in morphine can affect the biological activity associated with themolecule.