Biochemistry
Biochemistry
9th Edition
ISBN: 9781319114671
Author: Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher: W. H. Freeman
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I’m having hard time if this protein is folded or unfolded can you please help?
Under the stated conditions, the majority of the protein molecules in
solution would be
O in a roughly-equal mixture of unfolded and folded states.
O unfolded.
folded.
O in an indeterminate mixture of folded and unfolded states.
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Transcribed Image Text:Under the stated conditions, the majority of the protein molecules in solution would be O in a roughly-equal mixture of unfolded and folded states. O unfolded. folded. O in an indeterminate mixture of folded and unfolded states.
Protein folding
Consider the equilibrium between the unfolded and folded (native) states
of a protein, shown below:
unfolded, inactive;
collection of many,
many "random"
structures
folded, native,
active 3-dimensional
structure of protein
folding (or
renaturation)
unfolding (or
denaturation)
For the reaction written as shown (folding direction), for this protein
under certain solution conditions at 25 "C:
AH'fe
=-25.1 kJ/mol
folding
AS'
folding =-0.06 kJ / (mol K).
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Transcribed Image Text:Protein folding Consider the equilibrium between the unfolded and folded (native) states of a protein, shown below: unfolded, inactive; collection of many, many "random" structures folded, native, active 3-dimensional structure of protein folding (or renaturation) unfolding (or denaturation) For the reaction written as shown (folding direction), for this protein under certain solution conditions at 25 "C: AH'fe =-25.1 kJ/mol folding AS' folding =-0.06 kJ / (mol K).
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