Let’s return to your patient with sickle cell anemia.  Below is the RNA sequence from your patient and from her mother.  (The ••• represents another 30 nucleotides not written out here). The affected nucleotide is indicated in BOLD. Patient’s RNA:  5’ –CUAUGACAGAGUUC•••CAUUAGCCA – 3’ Mother’s RNA: 5’ –CUAUGACAGUGUUC•••CAUUAGCCA – 3’ C)  Write out the sequence of the normal beta-globin protein (as much as you can given the above info and below genetic code table) and indicate what would be different in the mutant protein.

Essentials of Pharmacology for Health Professions
7th Edition
ISBN:9781305441620
Author:WOODROW
Publisher:WOODROW
Chapter5: Abbreviations And Systems Of Measurement
Section: Chapter Questions
Problem 3CRQ
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Let’s return to your patient with sickle cell anemia.  Below is the RNA sequence from your patient and from her mother.  (The ••• represents another 30 nucleotides not written out here). The affected nucleotide is indicated in BOLD.

Patient’s RNA:  5’ –CUAUGACAGAGUUC•••CAUUAGCCA – 3’

Mother’s RNA: 5’ –CUAUGACAGUGUUC•••CAUUAGCCA – 3’

C)  Write out the sequence of the normal beta-globin protein (as much as you can given the above info and below genetic code table) and indicate what would be different in the mutant protein.  Don't forget your ends!

U
C
A
Tyr UGU Cys
UGC Cys
UUU
Phe
Phe
UCU
Ser
UAU
UUC
UC
Ser
UAC
C
Tyr
Stop UGA Stop A
Stop UGG Trp
U
UUA
Ser
Leu
UCA
UAA
UUG
Leu
UCG
Ser
UAG
CU
CUC
CCU
CGU Arg
U
Pro
Pro
Pro
Pro
CAU
CAC
CAA
CAG
His
His
Gln
Gln
Leu
Leu
CUA Leu
CUG Leu
C
CCA
CG
CGC
Arg
C
CGA Arg
CGG Arg
Asn AGU Ser
AUU
AUC
A
AUA lle
AUG Met ACG
lle
lle
ACU
ACC
ACA
Thr
AAU
AAC
AAA
Thr AAG
U
Asn AGC Ser
AGA Arg
G
Thr
Thr
Lys
A
Lys AGG Arg
Ala GAU
GAC
Ala
Asp GGU Gly
GUU Val
GCU
GCC
GUC Val
G
GUA Val
Asp GGC Gly
C
GCA Ala GAA
Ala
Glu
GGA Gly
A
GUG Val
GCG
GAG
Glu
GGG Gly
G
DUAG
DUAG
Transcribed Image Text:U C A Tyr UGU Cys UGC Cys UUU Phe Phe UCU Ser UAU UUC UC Ser UAC C Tyr Stop UGA Stop A Stop UGG Trp U UUA Ser Leu UCA UAA UUG Leu UCG Ser UAG CU CUC CCU CGU Arg U Pro Pro Pro Pro CAU CAC CAA CAG His His Gln Gln Leu Leu CUA Leu CUG Leu C CCA CG CGC Arg C CGA Arg CGG Arg Asn AGU Ser AUU AUC A AUA lle AUG Met ACG lle lle ACU ACC ACA Thr AAU AAC AAA Thr AAG U Asn AGC Ser AGA Arg G Thr Thr Lys A Lys AGG Arg Ala GAU GAC Ala Asp GGU Gly GUU Val GCU GCC GUC Val G GUA Val Asp GGC Gly C GCA Ala GAA Ala Glu GGA Gly A GUG Val GCG GAG Glu GGG Gly G DUAG DUAG
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ISBN:
9781305441620
Author:
WOODROW
Publisher:
Cengage