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- The large amount of energy used during aerobic exercise(e.g., running) requires large amounts of oxaloacetate.Explain why acetyl-CoA cannot be used to produceoxaloacetate in this circumstance. What is the sourceof oxaloacetate molecules during aerobic activity?asapThe enzyme is considered to be alan * ÇOO ÇOO Lactate dehydrogenase HO-C-H+ NAD C=0 + NADH + H CH: Pyruvate Lactate O Oxydoreductase O Isomerase O Hydrolase O Ligase O Dehydratase
- The pyruvate dehydrogenase complex catalyzes the oxidative decarboxylation of pyruvate to form acetyl‑CoA. E1E1 , E2E2 , and E3E3 are abbreviations for the enzymes of the complex. Classify the enzyme names, prosthetic groups, and reactions as E1E1 , E2E2 , or E3E3 .Identify the Krebs cycle enzyme that consumes a 3-carbon substrate molecule, producing a 2- carbon product molecule (attached to acetyl-CoA), along with NADH, and one molecule of CO2. succinyl CoA synthetase a-ketoglutarate dehydrogenase pyruvate dehydrogenase isocitrate dehydrogenase malate dehydrogenaseThe large amount of energy used during aerobic exercise (e.g., running) requires large amounts of oxaloacetate. Explain why acetyl-CoA cannot be used to produce oxaloacetate in this circumstance. What is the likely source of oxaloacetate molecules during aerobic activity?
- The enzyme, dihydrolipoamide dehydrogenase is present in both pyruvate dehydrogenase complex and α-ketoglutarate dehydrogenase complex. What type of reaction is catalyzed by these complexes? Describe the role of dihydrolipoamide dehydrogenase in these reactions.Complete the following description of the mechanism of the pyruvate dehydrogenase complex by using words provided. Not all words will be used. Each word will be used only one time. Three enzymes of the pyruvate dehydrogenase complex work together to catalyze the production of Acetyl CoA from Pyruvate. First, a 2-carbon unit composed of Carbons # ____ and ____ of Pyruvate are added to the co-enzyme ______ and whereas Carbon # ______ leaves as CO. The C-2 unit together with the co-enzyme is called ______ .The C-2 unit is then transferred to the 2nd co-enzyme ____, which is initially in it ___ state. The enzyme that catalyzes this step is ______.From here, the C-2 unit is transferred to form a _____ linkage with CoA-SH to generate_____If 1"co2 (radioactive carbon) were incorporated into the TCA cycle via the Pyruvate Carboxylase reaction which of the following molecules would contain radioactive carbon? Multiple answers: Multiple answers are accepted for this question Select one or more answers and submit. For keyboard navigation. SHOW MORE V a Oxaloacetate Citric acid Isocitric acid d a-Ketoglutarate e Succinyl-CoA Succinate Fumarate Malate b0
- Complete the following description of the mechanism of the pyruvate dehydrogenase complex by using words provided. Not all words will be used. Each word will be used only one time. 5 Three enzymes of the pyruvate dehydrogenase complex work together to catalyze the production of Acetyl CoA from Pyruvate. First, a 2-carbon unit composed of Carbons # Pyruvate are added to the co-enzyme and whereas Carbon # of leaves as CO» The C-2 unit together with the co-enzyme is called transferred to the 2nd co-enzyme 11 12 The C-2 unit is then which is initially in its state. The enzyme that catalyzes this step is From here, the C-2 unit is transferred to form a linkage with CoA-SH to generate Acetyl COA Oxidized Hydroxyethyl TPP Phosphodiester Reduced Hydroxypropiony! TPP Lipoamide E-1 NADH 3 Dihydrolipoyl dehydrogenase Thioester 2 HydroxyacetyITPp Dihydropipoyl Transacetylase Type the words in the correct order separated by commas. Example: 1, 3, E-1, Thioester, Lipoamide ...Pyruvate dehydrogenase activity is regulated in part by the concentration of acetyl COA. Name three metabolic pathways that can effect acetyl CoA levels, thus effecting the regulation of the Kreb Cycle.Explain why it makes metabolic sense for acetyl-CoA, which is not a substrate for gluconeogenesis, to activate pyruvate carboxylase.