Organic Chemistry: A Guided Inquiry
2nd Edition
ISBN: 9780618974122
Author: Andrei Straumanis
Publisher: Cengage Learning
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Two enzymes, E1 and E2, respectively catalyze the conversion of A to B, and B to C in two reactions in series. r1 and r2 denote reaction rates. Both reactions follow Michaelis-Menten kinetics.
Rm and Km for E1 and E2 are 5 mmol/(L*s), 2.5 mM, and 10 mmol/(L*s), 0.1 mM, respectively.
(a) At a steady-state, the cell converts 2 mmol/(L*s) of A to C. What are the intracellular concentrations of A and B?
(b) Now, the supply rate of A is increased to 4 mmol/(L*s), but E1 and E2 remain at same levels. What are the new concentrations of A and B?
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