Biochemistry
9th Edition
ISBN: 9781319114671
Author: Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher: W. H. Freeman
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Transporting anything through the mitochondrial membrane can be difficult. How do cells get Oxaloacetate in and out?
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- 15.13) The NADH that is produced by glycolysis is not able to pass through the inner mitochondrial membrane to enter the matrix region and undergo oxidative phosphorylation. Name the two processes in which the energy from NADH made in glycolysis can enter the mitochondrial matrix. ANSWER: 1) malate-aspartate shuttle 2) glycerol 3-phosphate shuttle EXPLANATION: Oxidative phosphorylation requires that NADH be located within the mitochondrial matrix. Since pyruvate oxidation/decarboxylation and the reactions of the citric acid cycle occur in the mitochondrial matrix, the NADH created in those processes can immediately undergo oxidative phosphorylation. The NADH that is produced by glycolysis is able to pass through the outer mitochondrial membrane and enter the intermembrane space; however, it is not able to pass through the inner mitochondrial membrane to enter the matrix region. In order for the energy from this NADH to be utilized, it must be processed through "NADH shuttles." The two…arrow_forwardHow does mitochondrial structure contribute to aerobic metabolism, particularly to the integration of the citric acid cycle and electron transport?arrow_forward______________ transfers carnitine from mitochondrial matrix to cytoplasm during the transport of fatty acid to mitochondria. Carnitine acyltransferase I CarnitineacyltransferaseII Transaminase Translocase Citric acid shuttlearrow_forward
- What thermodynamic force drives the transport of ADP and Pi into the mitochondrial matrix for ATP synthesis?arrow_forwardMany metabolites are transported either actively or passively across mitochondrial outerand inner membrane, like metabolites involved in urea cycle.(A) Besides the metabolites involved in urea cycle, name other metabolites that aretransported across the mitochondrial membranes and explain the biological importancefor transporting those metabolites (B) Mice fed with amphipathic chemical W, K and V were found to lose body weight. It wassuspected that W and K affected mitochondrial functions. The amount of foodconsumed by the mice was consistent throughout the experiment.i. When mice were fed with W, all mitochondrial proteins were function properly. Howdid W induce body weight loss? ii. When mice were fed with K, less complex III and IV were reduced in the electrontransport chains. Other mitochondrial proteins were function properly. How did Kinduce body weight loss? iii. When mice were fed with V, adenosine monophosphates (AMPs) were accumulated incytosol and mitochondria while no…arrow_forwardMake a rough drawing of the ATP synthase machinery within the mitochondrial membrane and specifically label the Fo and F1 subunits, as well as the C-ring, the a subunit, the y stalk and the a3ß3 hexamer.arrow_forward
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