Tobacco smoke from a typical cigarette contains 20-40 ng of benzo[a]pyrene, which can be oxidized by mammalian metabolic enzymes to form cancerogenic and mutagenic compound A. Carcinogenic properties of compound A arise from its ability to react with 2-amino group of guanine base, an essential component of DNA, according to the following scheme. Propose the structure of compound A indicating the stereochemistry where appropriate. DNA NH DNA-NH2 НО, HO Compound A OH HO ОН HO ОН
Tobacco smoke from a typical cigarette contains 20-40 ng of benzo[a]pyrene, which can be oxidized by mammalian metabolic enzymes to form cancerogenic and mutagenic compound A. Carcinogenic properties of compound A arise from its ability to react with 2-amino group of guanine base, an essential component of DNA, according to the following scheme. Propose the structure of compound A indicating the stereochemistry where appropriate. DNA NH DNA-NH2 НО, HO Compound A OH HO ОН HO ОН
Chapter14: Conjugated Compounds And Ultraviolet Spectroscopy
Section14.SE: Something Extra
Problem 50AP: -Ocimene is a pleasant-smelling hydrocarbon found in the leaves of certain herbs. It has the...
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