HO Si Grubbs' catalyst CH2Cl2 NH 25°C NH

Chemistry: The Molecular Science
5th Edition
ISBN:9781285199047
Author:John W. Moore, Conrad L. Stanitski
Publisher:John W. Moore, Conrad L. Stanitski
Chapter11: Chemical Kinetics: Rates Of Reactions
Section: Chapter Questions
Problem 83QRT
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One synthetic advantage of olefin metathesis is that the catalyst tolerates a variety of functional groups in the reactant. In a synthesis of the antiinfluenza drug Tamiflu (oseltamivir), ring-closing metathesis was used to prepare the highly functionalized cyclohexene derivative shown. What was the reactant?

HO
Si
Grubbs'
catalyst
CH2Cl2
NH
25°C
NH
Transcribed Image Text:HO Si Grubbs' catalyst CH2Cl2 NH 25°C NH
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