Three linked loci are evaluated to determine the recombination frequency of the loci. To set up the test cross, an individual that is true breeding dominant for all three phenotypes is crossed with an individual that is true breeding recessive for all three phenotypes. F1 offspring are crossed with individuals that are recessive for all phenotypes. The phenotypic results are shown in the table below.   Phenotype Number of Offspring Dominant 1, Dominant 2, Dominant 3 322 Dominant 1, Dominant 2, Recessive 3 82 Recessive 1, Dominant 2, Recessive 3 5 Dominant 1, Recessive 2, Dominant 3 2 Recessive 1, Dominant 2, Dominant 3 28 Recessive 1, Recessive 2, Dominant 3 89 Recessive 1, Recessive 2, Recessive 3 312 Dominant 1, Recessive 2, Recessive 3 25   1. Which two phenotypes are parental? 2. What is the map distance between locus 1 and locus 2? 3. What is the map distance between locus 1 and locus 3? 4. What is the map distance between locus 2 and locus 3? 5. Sketch a chromosome that maps the three loci based on your map distance calculations.

Human Anatomy & Physiology (11th Edition)
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ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
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  1. Three linked loci are evaluated to determine the recombination frequency of the loci. To set up the test cross, an individual that is true breeding dominant for all three phenotypes is crossed with an individual that is true breeding recessive for all three phenotypes. F1 offspring are crossed with individuals that are recessive for all phenotypes. The phenotypic results are shown in the table below.

 

Phenotype

Number of Offspring

Dominant 1, Dominant 2, Dominant 3

322

Dominant 1, Dominant 2, Recessive 3

82

Recessive 1, Dominant 2, Recessive 3

5

Dominant 1, Recessive 2, Dominant 3

2

Recessive 1, Dominant 2, Dominant 3

28

Recessive 1, Recessive 2, Dominant 3

89

Recessive 1, Recessive 2, Recessive 3

312

Dominant 1, Recessive 2, Recessive 3

25

 

1. Which two phenotypes are parental?

2. What is the map distance between locus 1 and locus 2?

3. What is the map distance between locus 1 and locus 3?

4. What is the map distance between locus 2 and locus 3?

5. Sketch a chromosome that maps the three loci based on your map distance calculations.

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