Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN: 9780134580999
Author: Elaine N. Marieb, Katja N. Hoehn
Publisher: PEARSON
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- A certain type of deafness in humans is inherited as an X-linked recessive trait. A man with this type of deafness married a normal woman, and they are expecting a child. They find out that they are distantly related. Part of the family tree is shown here.How would you advise the parents about the probability of their child being a deaf boy, a deaf girl, a normal boy, or a normal girl? Be sure to state any assumptions that you make.arrow_forwardShown below is a pedigree for a completely penetrant trait called Adams syndrome in which babies are born blind. This trait occurs when an allele of the adams gene is associated with ≥200 tandem trinucleotide repeats (the normal number is 10). First cousins, III-1 and III-2 married and their first child (IV-1) was blind. For their next child, they decided to do in vitro fertilization with III-1's sperm and III-2's eggs to generate six embryos (labeled E1-6). When each embryo contained eight cells, a single cell was removed and genomic DNA was isolated. PCR reactions using primers that flank the trinucleotide repeat region were then performed and the resulting fragments were fractionated on an agarose gel. PCR reactions using genomic DNA from III-1, III-2 and IV-1 were included as controls. The DNA was visualized using a fluorescent dye and the gel is shown below. Based on this information, select the best answer from the list to the questions below. || E1 = embryo 1 IV E1 E2 E3 E4 E5…arrow_forwardAdenike and her partner, Debare, are expecting their first child. Adenike is healthy as are her two sisters but her brother has PKU, a recessive disorder of the PAH gene. Genotypically he must be pah-/pah-. Neither of Adenike's parents has PKU but both of her grandmothers did. Debare is a carrier of Sickle Cell trait, which means he has one allele for wildtype hemoglobin (HbA) and one allele for Sickle Cell (HbS), making him HgA/HbS. More importantly, he has two alleles for Marfan Syndrome, a pleiotropic dominant disorder that can affect up to 30 different traits (M+/M+). No one in Debare's family has ever had PKU and no one in Adenike’s family has ever had Sickle Cell or Marfan Syndrome. They consult a genetics counselor over concern of the health of their baby. The genetics counselor collects the medical histories of three generations; their grandparents, their parents, and them. In her calculations, she produces a phenotypic key that indicates M = Marfan, Hb = sickle cell, and pah-…arrow_forward
- The pedigree below shows a family affected by a disease. Assume that the individuals marked with an asterisk (*) do not carry any allele associated with the affected phenotype, no other mutation spontaneously occurred, and complete penetrance. Answer the following questions below. Use the notation XR for the allele associated with the dominant phenotype and Xr for the allele associated with the recessive phenotype. Q1) Give the genotypes for as many individuals in the pedigree as possible.arrow_forwardWhat is the approximate percentage chance that individual V.2, shown in the pedigree diagram below will have inherited the X- linked recessive allele shown to be carried by his great-great-grandmother? Note: only type the number, not the percentage symbol. Answer: The chance that individual V.2 shown in the pedigree below has inherited the X-linked recessive allele shown to be carried by his great-great grandmother is approximately Blank 1 percent. 노 ㅍ먹이 12 I 마일 메인 de 먹어 요 58 ㅁ + ܡܐarrow_forwardDuchenne’s muscular dystrophy (DMD) is an X-linked disease that causes progressive muscle weakness and is often fatal. “XD” represents the wild type allele, and “Xd,” the mutant allele. Jonah is XDXd Y and his brother Pete is Xd Y. Jonah and Pete BOTH have DMD of equal severity and phenotypes. You might have thought Jonah’s DMD would be less severe given his genotype. To better understand the situation, you investigate Jonah’s Xist chromosome region in his defective muscle cells. Which of the following is consistent with his phenotype? (Select all that apply.) The Xd-containing chromosome is inactive in defective muscle cells. The XD-containing chromosome has a methylated Xist promoter. The XD-containing chromosome has an unmethylated Xist promoter. The Xd-containing chromosome is active in defective muscle cells.arrow_forward
- Can you please not type the answer can you write it on a paperarrow_forwardAdenike and her partner, Debare, are expecting their first child. Adenike is healthy as are her two sisters but her brother has PKU, a recessive disorder of the PAH gene. Genotypically he must be pah-/pah-. Neither of Adenike's parents has PKU but both of her grandmothers did. Debare is a carrier of Sickle Cell trait, which means he has one allele for wildtype hemoglobin (HbA) and one allele for Sickle Cell (HbS), making him HgA/HbS. More importantly, he has two alleles for Marfan Syndrome, a pleiotropic dominant disorder that can affect up to 30 different traits (M+/M+). No one in Debare's family has ever had PKU and no one in Adenike’s family has ever had Sickle Cell or Marfan Syndrome. They consult a genetics counselor over concern of the health of their baby. The genetics counselor collects the medical histories of three generations; their grandparents, their parents, and them. In her calculations, she produces a phenotypic key that indicates M = Marfan, Hb = sickle cell, and pah-…arrow_forwardThe discovery of sex-linked traits came from a genetic experiment on flies. A white eyed male fly was discovered. The trait was discovered to be sex-linked recessive. To guarantee that the white eye trait is recessive, he did a cross of XRXr and XrY. Complete the Punnett Square. State the genotypes and phenotypes of the offspring.arrow_forward
- Hello Heliodors! (cont.) Trait C The shape of a heliodor is an X-linked trait. Male heliodors inherit two X chromosomes, while the females inherit an X and a Y chromosome. The recessive allele codes for the common bell-shape while the dominant phenotype is a round shape U. Hudson is a round male and has offspring with Heidi, a bell-shaped female. They already have one daughter, Hannah, who is shaped like her mother. What percentage of their offspring will be carriers for the bell-shape trait? 75% 0% 25% 100% O 50%arrow_forwardAmanda Sefton (Daytripper) has normal fingers and toes and normal color vision. Her mother is normal in all respects, but her father is color blind (X- linked recessive) and syndactylous (autosomal dominant). Kurt Wagner (Nightcrawler) is color blind and syndictylous. His mother has normal color vision and normal fingers and toes, but he didn't know his father. As their genetic counselor, answer the following questions based on Kurt and Amanda marrying and starting a family. What is the probability of having a child that has syndactyly? (Enter your answer as a decimal; Example = 0.8782)arrow_forward
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