The reaction catalyzed by glyceraldehyde 3-phosphate dehydrogenase involves two "sub-reactions", one of which is unfavourable. How is the energy barrier of this unfavourable sub reaction overcome? A. through the formation and hydrolysis of a thioester bond using a cysteine molecule in the enzyme B. through the hydrolysis of an ATP molecule C. through the hydrolysis of a thioester bond in the substrate molecule D. the enzyme catalyzes the formation of a thioester bond E. none of these explanations describe how the energy barrier is overcome

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