Chemistry
10th Edition
ISBN: 9781305957404
Author: Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Publisher: Cengage Learning
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- For the determination of Pb in blood, a 5.00 mL sample was treated with trichloroacetic acid to precipitate the proteins. After centrifugation, the resulting solution was brought to pH 3 and extracted with two 5 mL portions of methyl isobutyl ketone containing the lead complexing agent APCD (ammonium 1-pyrrolidine carbodithiolate). The extract was drawn directly into an air-acetylene flame which produced an absorbance of 0.444 at 283.3 nm. Two 5.00 mL aliquots of solutions containing 0.250 and 0.450 ppm of Pb were subjected to the same sample treatment and the absorbance that occurred was 0.396 and 0.599 respectively. Calculate the concentration of Pb in µg/dL in the blood.arrow_forwardA buffer is made by adding 0.300 mol CH3COOH (acetic acid) and 0.300 mol CH3COONa (sodium acetate) to enough water to make 1.00 L of solution. Calculate the pH after 0.020 mol of NaOH is added to this buffer. (You may again ignore change in volume as a result of the addition.) Reference data: pK₂ of acetic acid is 4.74 (A) 4.74 (B) 4.68 (C) 4.80 (D) 3.60 (E) 12.0arrow_forwardTwo different proteins X and Y are dissolved in aqueous solution at 337.0 C. The proteins bind in a 1:1 ratio to form XY. A solution that is initially 1.460 mM in each protein is allowed to reach equilibrium. At equilibrium, 0.250 mM of free X and 0.250 mM of free Y remain. What is Kc for the reaction? 4.69e+04 The answer is not shown. 1.94e+04 2.63e+04 2.47e+04arrow_forward
- For two samples of cocaine, A was made up in an aqueous solution of pH 2.8, while B was made up in an aqueous solution of pH 9.8. The pka of cocaine is 8.6. Which of the two solutions is ready for cocaine extraction with hexane? Why?arrow_forward75mL of a 0.2M solution of a tripeptide Ser-Cys-His is adjusted to pH=8.6. The solution is then titrated with 50mL of 0.5M HCl. Calculate the new pH value of the tripeptide solution. (Relevant pKa values are: 2.2, 6.0, 8.3, and 9.6).arrow_forward50 mL of a 0.1M solution of tripeptide His-Arg-Ala is adjusted to its isoelectric point (pI). The solution is then titrated with 150 mL of 0.05M HCl. Then the solution is titrated with 65 mL of 0.1M NaOH. Calculate the final pH. (Relevant pKa values are 2.1, 6.0, 9.5 and 12.5.)arrow_forward
- Calculating the pl for an amino acid without an ionizable side chain is straightforward. Simply the average of the pKa values for the amine and the carboxylic acid. For example, for glycine, the calculation is as follows: pl = pKa-cooH + pKa-NH, 2 2.34 + 9.60 2 = 5.97 For amino acids with ionizable side chains, the pl is calculated by averaging the pKa values of either the two acidic groups or the two basic groups. For example, for glutamic acid, which has two acidic carboxylic acid groups, the calculation is as follows: Calculate the PI for the amino acid lysine (Lys). Calculating the pl for peptides and proteins is slightly more complicated but follows the same general concept.arrow_forwardIf the pKa of a weak acid is 5.65, then at what pH will there be a 50:50 mixture of the protonated and the deprotonated forms of the molecule? 5.35arrow_forwardThe triprotic form of the amino acid cysteine is shown below, along with the pK, value for each ionizable site. The isoelectric point (pl) for cysteine occurs at pH= 5.1. B 10.8 CH₂ SH C13 A LA -OH (1) What is the charge on the molecule at the isoelectric point? (2) In the predominant form of the molecule at the isoelectric point, is each of the sites (labeled A, B, and C) protonated or unprotonated? site A site B: site Carrow_forward
- A student added a total of 75 mL sodium hydroxide to titrate an amino acid solution with 0.5M NaOH. They also calculated that they added a total of 14 mL of sodium hydroxide to arrive at pH 2.6 and a total of 32 mL of sodium hydroxide to arrvive at pH 4.8.What was the initial concentration of the amino acid solution in milimolar (mM)? The calculations must be presented such that those can be recapitulated by the marker. Provide the answer with no decimal places. Show all details of your working out. State the answer in a full sentence.arrow_forwardConsider a "tripeptide" with the following features (at pH = 10.8) • The N-terminal amino acid is leucine • The middle amino acid is aspartate • The C-terminal amino acid is lysine i. What is the 1-letter symbol for each of these amino acids il. Calculate the net charge of the predominant ionic state of this tripeptide at pH 10.8. Show work.arrow_forwardA mixture of three proteins with pl = 7.5, 6.5, and 5.5 is separated using a DEAE-Sepharose column by eluting (washing) with buffer and NaCl. The column is eluted with aqueous buffer with a pH of 8.0, and an increasing [NaCl]. Which of the following proteins will elute from the column last? A The protein with pl = 5.5 B The protein with pl = 6.5 ☑ The protein with pl = 7.5 D These three proteins will not be separated, and will elute together. Your answerarrow_forward
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