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The man's genetic defect appears to be due to the mutation of the promoter region of a protein X. This protein is an activator of an enzyme Y that detoxifies reactive oxygen species and free radicals. DNA sequence analysis using the Sanger method of the mutated region around the TATA box detected the following products: Normal With Genetic Disorder ddNTP +ddTTP tetranucleotide tetranucleotide pentanucleotide pentanucleotide heptanucleotide heptanucleotide +ddATP mononucleotide mononucleotide trinucleotide trinucleotide hexanucleotide +ddCTP dinucleotide dinucleotide nonanucleotide hexanucleotide nonanucleotide +ddGTP octanucleotide octanucleotide decanucleotide decanucleotide What base was altered and to what was it changed?

The man's genetic defect appears to be due to the mutation of the promoter region of a protein X. This protein is an activator of an enzyme Y that detoxifies reactive oxygen species and free radicals. DNA sequence analysis using the Sanger method of the mutated region around the TATA box detected the following products: Normal With Genetic Disorder ddNTP +ddTTP tetranucleotide tetranucleotide pentanucleotide pentanucleotide heptanucleotide heptanucleotide +ddATP mononucleotide mononucleotide trinucleotide trinucleotide hexanucleotide +ddCTP dinucleotide dinucleotide nonanucleotide hexanucleotide nonanucleotide +ddGTP octanucleotide octanucleotide decanucleotide decanucleotide What base was altered and to what was it changed?

Human Anatomy & Physiology (11th Edition)
Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
Section: Chapter Questions
Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...
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A man has a very rare genetic disorder that affects the degradation of his hemoglobin. He experiences extreme excruciating pain when exposed to sunlight. The pain was due to the disintegration of the protoporphyrin rings by free radicals produced by high energy photons from light. The man's genetic defect appears to be due to the mutation of the promoter region of a protein X. This protein is an activator of an enzyme Y that detoxifies reactive oxygen species and free radicals. DNA sequence analysis using the Sanger method of the mutated region around the TATA box detected the following products: ddNTP Normal With Genetic Disorder tetranucleotide +ddTTP tetranucleotide pentanucleotide pentanucleotide heptanucleotide heptanucleotide +ddATP mononucleotide mononucleotide trinucleotide trinucleotide hexanucleotide +ddCTP dinucleotide dinucleotide nonanucleotide hexanucleotide nonanucleotide +ddGTP octanucleotide octanucleotide decanucleotide decanucleotide What base was altered and to what was it changed?
Transcribed Image Text:A man has a very rare genetic disorder that affects the degradation of his hemoglobin. He experiences extreme excruciating pain when exposed to sunlight. The pain was due to the disintegration of the protoporphyrin rings by free radicals produced by high energy photons from light. The man's genetic defect appears to be due to the mutation of the promoter region of a protein X. This protein is an activator of an enzyme Y that detoxifies reactive oxygen species and free radicals. DNA sequence analysis using the Sanger method of the mutated region around the TATA box detected the following products: ddNTP Normal With Genetic Disorder tetranucleotide +ddTTP tetranucleotide pentanucleotide pentanucleotide heptanucleotide heptanucleotide +ddATP mononucleotide mononucleotide trinucleotide trinucleotide hexanucleotide +ddCTP dinucleotide dinucleotide nonanucleotide hexanucleotide nonanucleotide +ddGTP octanucleotide octanucleotide decanucleotide decanucleotide What base was altered and to what was it changed?
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