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- 0.75/ Question 20 What is the difference between treppe and tetany? Mark ALL that apply. there is no summation in tetany there is no summation in treppe the contractions successively increase giving a "staircase" image treppe goes away after muscle is fully warmed up treppe is caused by gradual warming of an unstimulated muscle thus increasing diffusion of ions and protein movement needed to cause contractions.What is the maximum distance that diffusion is effective for oxygenating a muscle cell? How does the diffusion rate of oxygen play a role in limiting the fiber diameter for oxidative fibers. Use online sources and present answer as equations or graphically, but be sure that the values are expressed in terms of times and dimensions that are relevant for muscle fibers.96. An investigator is studying the contraction and relaxation of vascular smooth muscle in an experimental animal model. Which of the following describes the most likely order of events during this process? 0000000 200602 H) Myosin Light Chain Phosphorylation 1 2 2 3 3 4 4 Binding of Calcium to Calmodulin 3 1 4 2 4 2 3 Myosin Light Chain Dephosphorylation 2 3 4 3 4 2 1 2 Calcium Entry Into the Cell 4 2 3 1 1 1 3 1
- Explain how a ligand can bind to a membrane-bound receptor in asmooth muscle cell and cause sustained contraction for a prolongedperiod without a large increase in ATP breakdown (needs a proper explanation and not just 2-3 lines)Discuss the following statement: “The basal lam-ina of muscle fibers serves as a molecular bulletin board,in which adjoining cells can post messages that direct thedifferentiation and function of the underlying cells.”(1) The reading for today (Lieber and Ward, 2011) and your textbook describe the length-tension relationship of muscle, which can be explained by the figure below. Describe physiologically what is happening to explain the length-tension relationship, as shown by this figure. (a) 120 maximum tension (%) 100 80 60- 40 20 0 1.0 1.5 2.0 active (3) passive 2.5 3.0 3.5 4.0 length (um)
- Muscle Contraction In an experiment, the strength of a neural stimulus and the resulting muscle contraction are compared. A single motor neuron that synapses with one muscle fibre is observed in this experiment. One end of the muscle fibre is attached to a mass. The following data were obtained from the experiment. Analyze the data and answer the following questions. Number of Trials Strength of Stimulus (mV) Mass Lifted by Muscle Contraction (g) 1 20 2 40 3 60 50 4 80 50 100 Not Tested 120 50 *note that the voltage applied is positive in order to raise potential from resting to threshold Identify the manipulated, responding and controlled variables in the experiment described above. Strength of Stimulus Number of Muscle Fibre Stimulated Mass Lifted by Muscle ContractionCompare and contrast the major biochemical and mechanical properties of the three primary types of muscle fibers found in human skeletal muscle.An investigator is studying the electrophysical properties of gastrointestinal smooth muscle cells using microelectrodes. He measures the resting membrane potential of a cell to be -70 mV. The equilibrium potentials of different ions involved in generating the membrane potential are shown. ENa Ek Eca EM² Ecr +65 mV -85 mV +120 mV +10 mV -85 mV Which of the following is the most important contributor to the difference between the resting membrane potential and the equilibrium potential of potassium?
- 3.4. About human skeletal muscle contraction, what are the correct statements? PHYSIOLOGY_basic (OJO) A muscle fiber is made by the parallel apposition of sarcomers. Generation of force relies on the formation of cross-bridges between actin and myosin filaments. In the process of contraction, adenosine triphosphate (ATP) is required both to drive the actin-myosin association-dissociation cycle and to recycle calcium back to the endoplasmic reticulum. Each muscle fiber is innervated by one neuron only. T tubules are plasma membrane invaginations of the sarcolemma that allow excitation-contraction coupling.How fast could a non-muscle cell make a contraction compared to a muscle cell if the relative rates of myosin walks on F-actin are 4.5 μm/sec and 0.04 μm/sec for myosin II and I respectively?As mentioned in class, one additional major use of ATP in skeletal muscle (besides powering the myosin heads) is the recycling of calcium ions back into the sarcoplasmic reticulum after depolarization. The resting concentration of Ca++ in the muscle cell cytoplasm is about 50-100 nM, and the spike concentration after depolarization is about 10-20 μΜ. a) Consider a single sarcomere. What is the number of free calcium ions within the sarcomere at rest? What is the number of free calcium ions after depolarization? b) The major ion pump responsible for calcium ion recycling is SERCA (sarco/endoplasmic reticulum calcium ATPase). SERCA uses one molecule of ATP to pump two calcium ions, and the resting level can be restored in about 10-20 ms. How many molecules of ATP are used in a single sarcomere for pumping calcium in a single "twitch"? c) Assume that a single "twitch" is sufficient to drive one sarcomere from its fully extended length (about 2.5 µm) to its fully contracted length (about 1…
