The company produces a whole broth, containing 4 wt% solids with a bioproduct concentration of 1.4 g/L, atvolumetric flow rates of up to 200 mL/minute. To separate the whole broth and bioproducts, the company is considering processing the whole broth, without first removing the solids, in a Karr extractor. Process viability has been confirmed by tests in a small glass Karr column, which has an inside diameter of 2.54 cm and a plate-stack height of 3.05 m. The plates, of stainless steel with 8-mm diameterholes and a 62% open area, are on 51-mm plate spacings. The strokeheight is 19.1 mm and the SPM can be varied from 220 to 320. The tests were conducted with a suitable solvent, chloroform, which has a partition coefficient for the bioproduct of 2.68, which is constant in the dilute region. The tests sought to extract 99.5% of thebioproduct.The optimal test conditions for this extent of extraction were found to be F1 = 120 mL/minute and S1=180 mL/minute at SPM1 = 250. Scale these results up to a commercial unit that can process 1,325 L/h of feed.
The company produces a whole broth, containing 4 wt% solids with a bioproduct concentration of 1.4 g/L, atvolumetric flow rates of up to 200 mL/minute. To separate the whole broth and bioproducts, the company is considering processing the whole broth, without first removing the solids, in a Karr extractor. Process viability has been confirmed by tests in a small glass Karr column, which has an inside diameter of 2.54 cm and a plate-stack height of 3.05 m. The plates, of stainless steel with 8-mm diameter
holes and a 62% open area, are on 51-mm plate spacings. The stroke
height is 19.1 mm and the SPM can be varied from 220 to 320. The tests were conducted with a suitable solvent, chloroform, which has a partition coefficient for the bioproduct of 2.68, which is constant in the dilute region. The tests sought to extract 99.5% of thebioproduct.The optimal test conditions for this extent of extraction were found to be F1 = 120 mL/minute and S1=180 mL/minute at SPM1 = 250. Scale these results up to a commercial unit that can process 1,325 L/h of feed.
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