The accumulation of reactive oxygen species (ROS) can have particularly detrimental effects in cells. One way in which cells combat ROS is through detoxification enzymes that operate in the mitochondria and turn the ROS into more stable products. Even so, aging is an inevitable consequence of the accumulation of ROS in our cells. Which of the following statements about aged cells are correct, in reference to reactive oxygen species?
1. Aged cells may show more signs of ROS damage.
2. Aged cells occur because we are more exposed to radiation and air pollution later in our lives.
3. Aged cells could benefit from a greater dietary intake of an antioxidant like Vitamin C.
4. The accumulation of ROS that ages our cells occurs because the mitochondria stops functioning.
A.
1, 2 and 3
B.
1 and 3
C.
2 and 4
D.
4 only
E. All of 1, 2, 3 and 4 are correct.
Trending nowThis is a popular solution!
Step by stepSolved in 2 steps
- The biomolecular interaction between protein receptors and ligands is similar to that of en- zymes and substrates, which depends in part on the shape of the protein. The shape of a protein, in turn, depends on the presence of appropriate chemical bonds in the protein. Many common medications function by altering the interactions between protein receptors and ligands, thereby interfering with the normal response of a cell to specific signals. Which of the following best describes a mechanism by which a drug might interfere with a normal cellular response? A B A medication causes the cell to become more permeable and unable to maintain the conditions that allow a normal response. с A medication interrupts the electron transport chain in a cell and makes it unable to syn- thesize sufficient ATP. D A medication enters the nucleus of a cell and alters the nucleic sequence for a specific receptor protein. A medication enters a target cell and acts as an inhibitor to an intercellular protein…arrow_forwardProtein phosphorylation and dephosphorylation are important regulatory mechanisms. Protein kinases attach phosphoryl groups to target proteins, while only a phosphatase removes the phosphoryl group. What does this method of covalent control cost in terms of energy?arrow_forwardAging is associated with a decline in mitochondrial function. What would you expect to see when you stimulate beta-cells isolated from aged mice with glucose compared to the same experiment in beta-cells from young mice? increased oxygen consumption in the aged beta-cells decreased levels of intracellular potassium in the aged beta-cells increased levels of intracellular calcium in the aged beta-cells increased levels of insulin secretion in the aged beta-cells beta-cell function will not differ between the aged and young beta-cellsarrow_forward
- If there was a molecule that causes Hb to be more stable in the T state, this molecule would: a. Generally, raise the affinity of Hb for O2 b. Generally, lower the affinity of Hb for O2 c. Generally, cause Mb to favor the R state while Hb is in the T state d. Generally, cause Hb to dissociate into αβ dimersarrow_forwardSome strains of bacteria or microorganisms have developed toxins that can modify the activity of the alpha subunit of G proteins which results in disease. For ex. cholera toxin, produced by Vibrio cholerae, causes ADP ribosylation of the stimulatory Gαs subunit of G proteins. This modification abolishes the GTPase of Gαs, and results in an αs subunit that is always in the “on” or active state. It results in continuous stimulation of adenylyl cyclase (AC). The main cells affected by this are the epithelial cell in gastrointestinal tract. Knowing this altered activity of AC, explain why patients affected by this toxin experience severe diarrhea and dehydration that may result in death.arrow_forwardFamilial hypercholesterolemia is a genetic condition characterized by an absence of functional LDL receptors on the surface of cells. Patients who are homozygous for familial hypercholesterolemia usually die of coronary artery disease in childhood. Which of the following disorders could mimic the symptoms of familial hypercholesterolemia? (A) LDL receptor endocytosis machinery is non-functional (B) lack of ATP allosteric site on AMPK(C) Golgi proteases that cleave SREBP are not synthesized (D) mutation in the HMG CoA reductase SRE sequence. (E) inability to secrete VLDL from the liverarrow_forward
- Absorbed from the intestines into the blood, nitrites (NO2-) interact with the hemoglobin of the blood and block its respiratory function, turning part of the hemoglobin (HbFe2+) into methemoglobin (HbFe3+), unable to transfer oxygen from the lungs to tissues. With the formation of a large amount of methemoglobin, oxygen starvation of tissues occurs, which can cause damage to the central nervous system.10 to 20 % - of methemoglobin (HbFe3+) - asymptomatic cyanosis,20 to 50% of methemoglobin (HbFe3+) - hypoxia develop,> 50% of methemoglobin (HbFe3+) - the person will die.The body weight of the average person is 60 kg. Blood mass averages 8% of a person’s body weight; blood density ρ = 1,050 g/cm3, the hemoglobin (Hb) content in it is 14 g per 100 ml.molecular weight of hemoglobin 65-68 kg/mol (use 68 kg/mol for calculation). Assume that 1 mole of hemoglobin reacts with one mole of nitrite ion to form 1 NO molecule:HbFe2+ + NO2- → HbFe3+ + NOwill a 290 mg dose of sodium nitrite be…arrow_forwardPhosphofructokinase (PFK) catalyzes a key step in glycolysis. This enzyme is composed of three distinct subunits, muscle (M), liver (L) and platelet (P), which are expressed in different tissues. Mature human muscle contains exclusively the M isoform, while red blood cells express both M & L subunits. PFK gene mutations lead to M protein deficiency, intolerance to vigorous exercise and may lead to hemolytic anemia (Tarui disease). Which of the following can you conclude from the above information? Select all that apply. The muscle cells will be able to generate ATP through oxidative phosphorylation in the presence of oxygen U There may be a total lack of PFK activity in muscle O The red blood cells will be able to generate ATP through oxidative phosphorylation in the presence of oxygen U Hemolytic anemia may be due to instability of the L subunits in red blood cellsarrow_forward
- Human Anatomy & Physiology (11th Edition)BiologyISBN:9780134580999Author:Elaine N. Marieb, Katja N. HoehnPublisher:PEARSONBiology 2eBiologyISBN:9781947172517Author:Matthew Douglas, Jung Choi, Mary Ann ClarkPublisher:OpenStaxAnatomy & PhysiologyBiologyISBN:9781259398629Author:McKinley, Michael P., O'loughlin, Valerie Dean, Bidle, Theresa StouterPublisher:Mcgraw Hill Education,
- Molecular Biology of the Cell (Sixth Edition)BiologyISBN:9780815344322Author:Bruce Alberts, Alexander D. Johnson, Julian Lewis, David Morgan, Martin Raff, Keith Roberts, Peter WalterPublisher:W. W. Norton & CompanyLaboratory Manual For Human Anatomy & PhysiologyBiologyISBN:9781260159363Author:Martin, Terry R., Prentice-craver, CynthiaPublisher:McGraw-Hill Publishing Co.Inquiry Into Life (16th Edition)BiologyISBN:9781260231700Author:Sylvia S. Mader, Michael WindelspechtPublisher:McGraw Hill Education