ТАBLE 3.2 pk, Values of Common Amino Acids Acid a-COOH a-NH,* RH or RH Gly 2.34 9.60 Ala 2.34 9.69 Val 2.32 9.62 Leu 2.36 9.68 Ile 2.36 9.68 Ser 2.21 9.15 Thr 2.63 10.43 Met 2.28 9.21 Phe 1.83 9.13 Tip 2.38 9.39 Asn 2.02 8.80 Gln 2.17 9.13 Pro 1.99 10.6 Asp 2.09 9.82 3.86* Glu 2.19 9.67 4.25* His 1.82 9.17 6.0* Cys 1.71 10.78 8.33* Tyr 2.20 9.11 10.07 Lys 2.18 8.95 10.53 Arg 2.17 9.04 12.48 *For these amino acids, the R group ionization occurs before the a-NH,* ionization.

Curren'S Math For Meds: Dosages & Sol
11th Edition
ISBN:9781305143531
Author:CURREN
Publisher:CURREN
Chapter9: Parenteral Medication Labels And Dosage Calculation
Section: Chapter Questions
Problem 6.4P
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Based on the information in Table 3.2, is there any amino acid that could serve as a buffer at pH 8? If so, which one?

ТАBLE 3.2
pk, Values of Common Amino Acids
Acid
a-COOH
a-NH,*
RH or RH
Gly
2.34
9.60
Ala
2.34
9.69
Val
2.32
9.62
Leu
2.36
9.68
Ile
2.36
9.68
Ser
2.21
9.15
Thr
2.63
10.43
Met
2.28
9.21
Phe
1.83
9.13
Tip
2.38
9.39
Asn
2.02
8.80
Gln
2.17
9.13
Pro
1.99
10.6
Asp
2.09
9.82
3.86*
Glu
2.19
9.67
4.25*
His
1.82
9.17
6.0*
Cys
1.71
10.78
8.33*
Tyr
2.20
9.11
10.07
Lys
2.18
8.95
10.53
Arg
2.17
9.04
12.48
*For these amino acids, the R group ionization occurs before the a-NH,* ionization.
Transcribed Image Text:ТАBLE 3.2 pk, Values of Common Amino Acids Acid a-COOH a-NH,* RH or RH Gly 2.34 9.60 Ala 2.34 9.69 Val 2.32 9.62 Leu 2.36 9.68 Ile 2.36 9.68 Ser 2.21 9.15 Thr 2.63 10.43 Met 2.28 9.21 Phe 1.83 9.13 Tip 2.38 9.39 Asn 2.02 8.80 Gln 2.17 9.13 Pro 1.99 10.6 Asp 2.09 9.82 3.86* Glu 2.19 9.67 4.25* His 1.82 9.17 6.0* Cys 1.71 10.78 8.33* Tyr 2.20 9.11 10.07 Lys 2.18 8.95 10.53 Arg 2.17 9.04 12.48 *For these amino acids, the R group ionization occurs before the a-NH,* ionization.
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