Superantigens that bind to the T cell receptor CD28 stimulate T cell activation and proliferation in the absence of antigen presenting cell. stimulation from the cytokine none of these B7 MHC-II-peptide antigen all of these
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- Which of the following is not associated with killing by a cytotoxic T cell? View Available Hint(s) for Part A granzyme CD95 perforin IL-4There are several important mechanisms for generating diversity in immunoglobulin and T cell receptors. Explain the similarities and differences in mechanisms that generates diversity in these receptors.Compare B cell receptors and T cell receptors for the following criteria: BCR TCR Tyrosine kinases Adaptors and scaffold proteins Phospholipases and lipid kinases GTPases, serine/threonine kinases and phosphatases Transcription factors, cytoskeletal changes, adhesion, metabolism
- At first glance, it would seem a dangerous strategyfor the thymus to actively promote the survival, matura-tion, and emigration of developing T cells that bind weaklyto self peptides bound to self MHC molecules. Would itnot be safer to get rid of these T cells, along with those thatbind strongly to such self-peptide–MHC complexes, as thiswould seem a more secure way to avoid autoimmune reac-tions?What distinguishes MHC I from MHC II? a-aquisition of antigenic peptide in the cytoplasm b-cross-presentation of antigegn to CD4 T cells c- presentation of peptides to the T cell receptor d-binding of a B-amino acid peptide e- presentation of antigenic peptides to CD4 T cellsAll of the following statements concerning regulatory T cells (Treg) are correct, EXCEPT: The regulatory cytokines produced by regulatory T cells are IL-12 and TGF-B O Thymocytes that recognize self-antigen in the thymus with a certain affinity become natural (central) regulatory T cells O In the periphery T cells that recognize self-antigen in the presence of TGF-B become induced regulatory T cells O A Treg cell can suppress self-reactive lymphocytes that recognize peptides different from that recognized itself provided that the peptides are derived from the same tissue O A Treg cell can suppress self-reactive lymphocytes that recognize peptides different from that recognized by itself provided that the peptides are presented by the same antigen-presenting cell (APC)
- Class II MHC proteins display what kind of antigens? What class of T cell recognizes antigens bound to class II MHC? What types of cells display these proteins?Why is the concentration of this ligand for the NK-cell receptor CD94:NKG2A. on the target cell an effective measure of the presence or absence of classical MHC class I molecules?Which of the following is MOST critical for the activation of naïve T cells during priming by DCs? Signaling through both the TCR and the co-stimulatory receptor CD28 Recognition of antigen by CD4 or CD8 molecules The presence of a chemokine gradient Production of TNFalpha by DCs as a result of their exposure to PAMPS or DAMPS Affinity maturation
- Activation of which of the following do not cause phagocytosis to occur O Pattern Recognition Receptors O Fc Receptors O B-Cell Receptor T-Cell ReceptorClass switching is initiated by T-cell activation via CD40 ligation. You are working with a mouse model that is deficient in CD40L. What kind of phenotype would you expect to see in the mouse? a lack of memory T cells a lack of antibodies of classes other than IgM extremely high concentrations of IgE extremely low concentrations of IgDMatch the term with its correct description. selection for thymocytes which recognize self MHC molecules elimination of thymocytes which recognize self continued alpha chain rearrangement until a functional TCR is generated process by which autoreactive thymocytes are eliminated in the thymus activation of a T-cell only if the appropriate MHC molecule presents an antigenic peptide ✓Choose... Apoptosis MHC restriction Positive selection Negative selection T-cell receptor editing Choose...