Sickle cell anemia causes hemoglobin, the oxygen - carrying molecule of red blood cells, to be misshapen resulting in disease. "H" is the normal hemoglobin allele and "h" is the allele for sickle - cell shaped hemoglobin. In order to get the disease, a person must have a recessive genotype (hh). Two people with normal red blood cells are carriers of the gene - they have m genotypes Hh. Questions: a. What are the possible genotypes of the eggs the woman can produce? b. What are the possible genotypes of the sperm the man can produce? c. What is the genotypic ration for the offspring? d. What is the phenotype ratio for the offspring? e. What is the couple's chance of having a child a sickle

Queen Victoria had 1 (Leopold) out of four male offspring with hemophilia. What was the probability of this scenario?   Hemophilia is known as "The royal disease" because many of the European royal families had members afflicted with it. A really famous case was Queen Victoria's (1819-1901) descendants who spread the disease across Europe, from Spain to Russia. You can see the pedigree of Queen Victoria's family here:Hemophilia is an X-linked recessive disease. With the information provided, please answer the following questions:

Sickle cell anemia is an inheritable red blood cell disorder that results in sickle-shaped red blood cells. The sickle-shaped red blood cells can stick to blood vessel walls and cause a blockage or slow the movement of blood throughout the body.   Individuals who are heterozygous produce both normal and sickle-shaped red blood cells which gives them resistance to malaria but they do not develop sickle cell anemia (so heterozygotes are unaffected on the pedigree).Let HbS be the allele for sickle cell anemia and let HbA be the allele for normal red blood cells.   Which of the following rows provides the correct genotypes for individuals I-2, I-4, II-1, and III-1? Select one: a. I-2 I-4 II-1 III-1 HbA_ HbAHbS HbAHbS HbA_ b. I-2 I-4 II-1 III-1 HbA_  HbAHbS HbAHbS HbAHbS c. I-2 I-4 II-1 III-1 HbAHbS HbAHbS HbAHbS HbAHbS d. I-2 I-4 II-1 III-1 HbAHbA HbAHbA HbAHbA HbAHbA

Mr. and Mrs. Flynn are concerned because their new baby doesn't resemble either of them and has type O blood. Mr. Flynn is type A and Mrs. Flynn is type B. They're sure that it's impossible to have a baby with a different blood type than the parents, and so they conclude that a mistake has been made. Are they correct? Explain your answer. Be specific. Use the correct blood alleles (IA, IB, i) in your explanation.   genotypes:   Mr. Flynn _________         Mrs. Flynn __________           their baby ___________ Display keyboard shortcuts for Rich Content Editor

Sickle cell anemia is an inheritable red blood cell disorder that results in sickle-shaped red blood cells. The sickle-shaped red blood cells can stick to blood vessel walls and cause a blockage or slow the movement of blood throughout the body.   Individuals who are heterozygous produce both normal and sickle-shaped red blood cells which gives them resistance to malaria but they do not develop sickle cell anemia (so heterozygotes are unaffected on the pedigree).Let HbS be the allele for sickle cell anemia and let HbA be the allele for normal red blood cells.   Which of the following rows provides the correct genotypes for individuals I-2, I-4, II-1, and III-1? Select one: a. I-2 I-4 II-1 III-1 HbA_ HbAHbS HbAHbS HbA_ b. I-2 I-4 II-1 III-1 HbA_  HbAHbS HbAHbS HbAHbS c. I-2 I-4 II-1 III-1 HbAHbS HbAHbS HbAHbS HbAHbS d. I-2 I-4 II-1 III-1 HbAHbA HbAHbA HbAHbA HbAHbA

You are trying to find a blood donor to help treat some of your patients. The C-yonce and Kay-Z have 3 children with blood types A , B, and O. The youngest with blood type O needs a transfusion and you're trying to figure out if either of the parents are a match so you test the parent genotypes. Note: Alleles for each blood type are expressed as follows: blood type A= I^A blood type B= I^B blood type O= i Hint: Remember that 2 alleles contribute to a persons blood type. Pay attention to dominant and recessive relationships among the alleles.     1-C-yonce is type B. What must her genotype be? 2-What must Kay-Z’s genotype be? 3-Which parent can give blood to their child ? 4-After running lab tests, it was discovered that the children's blood types were reported incorrectly.(This does not affect the genotypes entered for C-yonce and Kay-Z in the previous questions.) Their youngest actually has blood type AB, and still needs a blood transfusion.  Which parent can donate blood to the child…

Blood types in humans are caused by a combination of two of three possible alleles - IA, IB, and i. The i allele is recessive and individuals homozygous for this allele have blood types O.  Blood type A may be due to either homozygous condition or the IA i   Blood type AB is caused by having a copy of both the IA and IB alleles.  Rh factor is another “marker” on human red blood cells and is either positive (dominant—RR or Rr) or negative (recessive—rr). Franks has blood type A-negative. Frank’s father is B-positive and his mother is AB-positive. Frank marries Susan, a woman that is B-positive.  Susan’s mother is A-negative and her father is AB-positive.  Give the genotype of all of the individuals mentioned above.   b. Give the genotypes and phenotypes of the possible offspring from this marriage

In humans, blood type AB is a codominant trait.  Suppose Jim has blood type AB (IAIB) and his wife has blood type O (ii).  What are the possible genotypes and blood types of their children?

Adenike and her partner, Debare, are expecting their first child. Adenike is healthy as are her two sisters but her brother has PKU, a recessive disorder of the PAH gene. Genotypically he must be pah-/pah-. Neither of Adenike's parents has PKU but both of her grandmothers did. Debare is a carrier of Sickle Cell trait, which means he has one allele for wildtype hemoglobin (HbA) and one allele for Sickle Cell (HbS), making him HgA/HbS. More importantly, he has two alleles for Marfan Syndrome, a pleiotropic dominant disorder that can affect up to 30 different traits (M+/M+). No one in Debare's family has ever had PKU and no one in Adenike’s family has ever had Sickle Cell or Marfan Syndrome. They consult a genetics counselor over concern of the health of their baby. The genetics counselor collects the medical histories of three generations; their grandparents, their parents, and them. In her calculations, she produces a phenotypic key that indicates M = Marfan, Hb = sickle cell, and pah-…

Cystic fibrosis (CF) is an autosomal recessive trait. A three-generation pedigree is shown below for a family that carries the mutant allele for cystic fibrosis. Note that carriers are not colored in to allow you to figure out their genotypes.      Normal allele =  F      CF mutant allele =  f        What is the genotype of individual #13? A) ff B) FF C) Ff  D) it is impossible to tell