Human Anatomy & Physiology (11th Edition)
Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN: 9780134580999
Author: Elaine N. Marieb, Katja N. Hoehn
Publisher: PEARSON
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**Question 4: DNA Sequence Analysis**

Shown here is a DNA sequence. The promoter is highlighted in yellow, and the terminator is highlighted in blue. Transcription begins 10 bases from the promoter. The A marked with a star is replaced by a T. What kind of mutation is this?

**DNA Sequence:**

**5’ - ATATTTGCTAGACTGT** CGCTCCGGATCTGTAGTCGTAGCTCGGATGCTGAGTAGCGTCCGCGTCTAACGTGCTTTTTAC - 3’  
**3’ - TATAAACGATCTGACA** GCGAGGCCTAGACATCAGCATCGAGCCTACGACTCATCGCAGGCGCAGAATTGCACGAAAATG - 5’

- **Promoter**: Highlighted in yellow
- **Terminator**: Highlighted in blue

**Mutation Question:**
The A marked with a star (*) is replaced by a T. 

**Options for Mutation Type:**
- Silent
- Missense
- Nonsense
- Frameshift

**Explanation:**

- **Promoter Region**: The promoter is a sequence of DNA needed to turn a gene on or off. In this sequence, it is highlighted in yellow.
  
- **Terminator Region**: The terminator is a sequence of DNA that signals the end of transcription. In this sequence, it is highlighted in blue.

- **Mutation Analysis**: The mutation involves a substitution of adenine (A) by thymine (T) at the position marked by a star. This can be analyzed to determine the type of mutation it causes (silent, missense, nonsense, or frameshift).
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Transcribed Image Text:**Question 4: DNA Sequence Analysis** Shown here is a DNA sequence. The promoter is highlighted in yellow, and the terminator is highlighted in blue. Transcription begins 10 bases from the promoter. The A marked with a star is replaced by a T. What kind of mutation is this? **DNA Sequence:** **5’ - ATATTTGCTAGACTGT** CGCTCCGGATCTGTAGTCGTAGCTCGGATGCTGAGTAGCGTCCGCGTCTAACGTGCTTTTTAC - 3’ **3’ - TATAAACGATCTGACA** GCGAGGCCTAGACATCAGCATCGAGCCTACGACTCATCGCAGGCGCAGAATTGCACGAAAATG - 5’ - **Promoter**: Highlighted in yellow - **Terminator**: Highlighted in blue **Mutation Question:** The A marked with a star (*) is replaced by a T. **Options for Mutation Type:** - Silent - Missense - Nonsense - Frameshift **Explanation:** - **Promoter Region**: The promoter is a sequence of DNA needed to turn a gene on or off. In this sequence, it is highlighted in yellow. - **Terminator Region**: The terminator is a sequence of DNA that signals the end of transcription. In this sequence, it is highlighted in blue. - **Mutation Analysis**: The mutation involves a substitution of adenine (A) by thymine (T) at the position marked by a star. This can be analyzed to determine the type of mutation it causes (silent, missense, nonsense, or frameshift).
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