Show the complete and detailed reaction mechanism (Curtius Rearrangement) of carboxylic acid 4 that resulted in the formation of isocyanate 5, which, upon electrocyclization furnished pyrrolo[2,3-c]quinoline 6. Intermediate 6 was subsequently transformed into triflate 7, and the total syntheses of marinoquinolines 3a, 3b, and 3e were accomplished by intro- ducing different substituents at the C4 position. (show movement of electrons, charges, arrows, reagents, conditions, biproducts etc. and provide short explanation)
Show the complete and detailed reaction mechanism (Curtius Rearrangement) of carboxylic acid 4 that resulted in the formation of isocyanate 5, which, upon electrocyclization furnished pyrrolo[2,3-c]quinoline 6. Intermediate 6 was subsequently transformed into triflate 7, and the total syntheses of marinoquinolines 3a, 3b, and 3e were accomplished by intro- ducing different substituents at the C4 position. (show movement of electrons, charges, arrows, reagents, conditions, biproducts etc. and provide short explanation)
Chapter24: Amines And Heterocycles
Section24.SE: Something Extra
Problem 78AP
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