
Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN: 9780134580999
Author: Elaine N. Marieb, Katja N. Hoehn
Publisher: PEARSON
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Transcribed Image Text:**Resting Membrane Potential - Data**
| Concentration (mM) | K⁺ Inside | K⁺ Outside | Na⁺ Inside | Na⁺ Outside | Membrane Voltage (mV) |
|---------------------|-----------|------------|------------|-------------|-----------------------|
| | 140 | 4 | 10 | 140 | -68.036 |
| | 140 | 100 | 10 | 140 | -22.5 |
| | 140 | 4 | 10 | 200 | -61.545 |
**Questions**
1. What was the effect of increasing extracellular K⁺ to 100 mM on the membrane's potential?
2. Explain why the above change occurred.
**Explanation of Data**
This table represents the changes in membrane voltage (mV) with different ionic concentrations (in mM) inside and outside the cell. The first row is the baseline scenario, with typical K⁺ and Na⁺ distribution, showing a membrane voltage of -68.036 mV. The second row indicates an increase in extracellular K⁺ concentration to 100 mM, resulting in a membrane voltage shift to -22.5 mV. The third row examines an increase in extracellular Na⁺ to 200 mM, with the voltage changing to -61.545 mV.
Readers are encouraged to consider how these changes affect the resting membrane potential, reflecting on the Nernst equation and the principles of ionic equilibrium across a cell membrane.
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