Q1: Determine the major product(s) of the following reaction with correct stereochemistry where applicable. H2SO4 (cat.) H) XH OH heat Br 1) MeOH SN1 Q2. Ranke the following in the order of increasing reactivity towards SN1 reaction. CH3 CH3 CH3 H2C CH2 CH3 CH3 H₂C CH2 CH3 CH3 H2C CH2 H3C Br H3C Br H3C CI Br I ။ III IV Least reactive Most reactive

4. Predict the product(s) for each of the following reactions and include stereochemistry when necessary. HI Os04. H2O2 1) O3, -78 °C 2) Me,S

iii) 10. For each of the following reactions, provide the structure of the major product and circle the predominant mechanism. Indicate the stereochemistry where necessary. VII) E1 E2 SN1 SN2 E1 E2 SN1 SN2 NaSH DMF H* CH3OH Br (CH3)3COK (CH3)3COH OH iv) HBr viil) E1 E2 E1 E2 SN1 SN2 SN1 SN2

Help find major products for each step

Predict the major products of each reaction and its stereochemistry. Write NR if none found.

For each of the following reactions, predict the major products. Include stereochemistry.

Are the products of the following reaction the same product (a single product that formed as a racemic mixture)?

None

2. How would you carry out each of the following syntheses? Each may require more than one step. а) CH3CH2C=CH ? CH3CH2CCH3 b) CH3CH2CH2C=CH CH3CH2CH2CHO C=CH CC-CH3 ?, H H d) CH3CH2CH2CH2C=CH TH CH3CH,CH2CH2 CH3 e) CH2CH3 (CH3}2CHCH2C=CH C=C (CH3)2CHCH2 H

Draw the major product of this reaction. Include stereochemistry if applicable. Use a dash or wedge bond to indicate the stereochemistry of substituents on asymmetric centers, where applicable. Ignore byproducts. CH3OH heat -Br Q