BACKGROUND: Sickle cell disease is caused by a change in the gene for hemoglobin, which isthe oxygen-carrying protein in red blood cells. Individuals who are homozygous for the sicklecell trait often cannot endure exercise. Individuals who are heterozygous for the trait can havesickle cell attacks under extreme conditions. Normal individuals (genotype: Hbnorm Hbnorm ) haveonly normal hemoglobin. Homozygous sickle cell individuals (genotype: Hbsc Hbsc ) 'have onlysickle cell hemoglobin. Heterozygous individuals (genotype: Hbnorm Hbsc ) have both normal andsickle cell hemoglobin.terry Smith collapsed while running a race for his track team. A doctor said he had a sickle cellattack. Genetic tests were run on several family members. The test results are shown below. AnX indicates that form of hemoglobin in red blood cells.PROBLEM: How can you determine the genotypes of people in a family?SubjectNormal HemoglobinSickle Cell HemoglobinJerryJerry's brotherJerry's younger sisterJerry's youngest sisterJerry's fatherJerry's grandfatherJerry's grandmotherPROCEDURE1. Use the background information and the genetic test results to answer questions 1-4.2. Use the background information and a Punnett square to help you answer question 5.ANALYZE AND CONCLUDE1. Are any of Jerry's siblings homozygous for the sickle cell trait? Are any of Jerry's siblingsheterozygous for the sickle cell trait?2. What genotype if Jerry's father?3. What genotypes are Jerry's grandparents?4. What is the genotype of Jerry's mother? Explain.5. If Jerry marries a female who is heterozygous for the sickle cell trait, what would be thepossible genotypes and phenotypes of their childres, according to your Punnett square?

Hbn Hbn =homozygous normalHbs Hbs = homozygous recessive with diseaseHbn Hbs= heterozygous normal

Answered: PROCEDURE 1. Use the background…

Human Biology (MindTap Course List)

11th Edition

ISBN:9781305112100

Author:Cecie Starr, Beverly McMillan

Publisher:Cecie Starr, Beverly McMillan

Chapter20: Chromosomes And Human Genetics

Section: Chapter Questions

Problem 5CT

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Sickle anemia is a favorable mutation. There is only one amino acid different in sickle haemoglobin (S) as compared with normal haemogloblin (A). Persons with sickle cell trait (AS) are able to survive in malarious areas. A couple each having sickle cell trait have five children. What is the probability that they will have a child with sickle disease?
Congenital pulmonary alveolar proteinosis is a rare lung disease in humans. The disease is caused by a recessive mutation in the gene CSF2RA. CSF2RA is located within a pseudoautosomal region of the X and Y chromosomes. The normal allele is notated as Cnorm, and the mutant allele is notated as Cmut. Suppose that a woman with Cnorm on both X chromosomes (XCnormyCnorm) has children with a man with Cmut on the X chromosome and Cnorm on the Y chromosome (XCmutyCnorm Select all possible genotypes of their offspring Select all possible genotypes of their offspring for males. for females. O xCnormy Cnorm O xCnormyCnorm O xCnormyCmut O xCmutyCmut O xCmutxCmut O xCmutyCnorm O xCnormyCmut
What is the frequency of sickle cell disease (anemia)? https://ghr.nlm.nih.gov/condition/sickle-cell-disease#inheritance https://www.cdc.gov/ncbddd/sicklecell/traits.html
explain pleiotropy in sickle cell disease.
The likelihood that a son of a patient with severe hemophilia A will have hemophilia is:
A father without hemophilia (X HY) has two daughters and two sons. Neither daughter has hemophilia. One son has hemophilia and the other does not. What is the genotype of the mother? O A XHXH O B. XHxh O c xhy O D. XHY acer
Given the information regarding sickle cell anemia, if two carriers were to have children, what would be the genotypes and phenotypes of their children? Would any of the children show symptoms of the disease?
For the following genotypes state the ABO blood phenotype. IAIA - IBIO - IOIO - IAIB –
Sickle cell anemia is caused by an individual carrying two recessive copies of the hemoglobin gene (hemoglobin gene is labeled Hb, and the recessive version is Hbs). Thus, to have sickle cell anemia, a person must have the genotype HbSHbS. A person that is HbAHbA carries two copies of the normal hemoglobin gene and does not have sickle cell anemia. A person that is heterozygous (HbAHbS) produces enough normal hemoglobin to not have sickle cell anemia but is also resistant to malaria. People that are heterozygous are called “carriers” because they carry the recessive allele but do not express the recessive phenotype. a. A couple are both resistant to malaria but do not have sickle cell anemia. Draw a Punnett square to represent this cross. b. What is the probability that the couple has three children where one child does not have a recessive allele, one child is resistant to malaria and does not have sickle cell anemia, and one child has sickle cell anemia?
Sickle cell anemia follows a single-gene pattern of inheritance, with two alleles: one allele (S) produces normal hemoglobin, and the other (s) produces abnormal hemoglobin. Describe the phenotype outcome for each of the three possible genotypes (SS, Ss and ss), with regard to sickle cell anemia and malaria.
In humans, hemophilia is a sex-linked trait. Females can be normal, carriers, or have the disease. Males will either have the disease or not (but they won’t ever be carriers). X H X H = female, non-hemophilic X H X h = female, carrier X h X h = female, hemophilia X H Y = male, non-hemophilic X h Y= male, hemophiliac a.) Show the cross of a man who has hemophilia with a woman who is a carrier. What is the probability that their children will have the disease? b.) A woman who is a carrier marries a non-hemophilic man. Show the cross. What is the probability that their children will have hemophilia? What sex will a child in the family with hemophilia be? c.) A woman who has hemophilia marries a non-hemophilic man. How many of their children will have hemophilia, and what is their sex?
Sickle-cell disease is an autosomal recessive genetic disorder. How many mutated hemoglobin alleles do people with sickle-cell disease have?

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