Please consider the pedigree below. There are no cases of false paternity. I A 1 2 II 2. (A 2 III AB IV 1 a. Which individual/s definitely has/have Bombay phenotype in the descendants of I-1 and I-2? b. What are the genotypes of individuals II-2 and III-2 at the ABO and H loci? Please label your answers a and b, Il-2: and III-2:.
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- While sitting at home during Movement Control Order (MCO) because of pandemic covid19, observe two different traits of a couple in your family (eg. your mom & dad or your sister & her husband or your brother & his wife, etc). Draw a genetic cross that involves cross of the parents with the chosen 2 pairs of their contracting traits. Imagine that the cross obeys the Mendelian Laws, show the cross and gametes production for each generation (P, F1 and F2). By Using a Punnet square as symbolic representation of the results for the cross, determine the phenotypes, genotypes, phenotypic ratio and genotypic ratio of F2 generation in the family.Blood types in humans are caused by a combination of two of three possible alleles - IA, IB, and i. The i allele is recessive and individuals homozygous for this allele have blood types O. Blood type A may be due to either homozygous condition or the IA i Blood type AB is caused by having a copy of both the IA and IB alleles. Rh factor is another “marker” on human red blood cells and is either positive (dominant—RR or Rr) or negative (recessive—rr). Franks has blood type A-negative. Frank’s father is B-positive and his mother is AB-positive. Frank marries Susan, a woman that is B-positive. Susan’s mother is A-negative and her father is AB-positive. Give the genotype of all of the individuals mentioned above. b. Give the genotypes and phenotypes of the possible offspring from this marriageIn pigs, erect ears is dominant (E) to drooping ears (e). The gene for ear position is autosomal. Create a Punnett square for each test cross possibility. Write a summary sentence explaining the result of each test cross possibility. Possiblility #1 Parent genotypes: _ _ x _ _ Summary sentence explaining the expected results: Possiblility #2 Parent genotypes: _ _ x _ _ Summary sentence explaining the expected results:
- A research team genotyped hundreds of families affected by haemophilia. Among those families, they found many that had a pattern of RFLP like that of daughter1, her husband and her parents. When they genotyped the children in those families, they found the following association between the RFLP and hemophilia: The numbers at the bottom indicate the number of progeny with that combination of hemophilia phenotype and RFLP polymorphism found among these families. What is the map distance between the RFLP and the hemophilia gene? Show your work.Please consider the pedigree below. There are no cases of false paternity. I B II A 2 3 III AB (A IV в 1 a. Which individual/s definitely has/have Bombay phenotype in the descendants of I-1 and I-2? b. What are the genotypes of individuals II-2 and III-2 at the ABO and H loci?For the following question, please explain in as much detail as possible. Below is a human pedigree and corresponding RFLP data. Explain the type of transmission for the type of albinism depicted in this family. What does the pedigree tell you about the individual labeled Y's genotype? There are two genes known to cause this type of albinism found in this family: OCA1 and OCA2. If we know 1 (albino great grandmother) had mutation in OCA1 which gene would you hypothesize is mutated in individual Y's genome? Explain your reasoning. generations Key: D ở abino Ped. III2 II13 IV1 IV 2 IV3 IV4 IV5 IV6 III13 III14 IV 15 IV16 IV17 ID (P) (Q) (X) (Y) Band size 20kb 15kb X 12kb 10kb X X 8kb X X X 5kb X X X X X X X X 3kb 2kb
- If the following pedigree is for a family who has sickle cell anemia, which individuals are definitely carriers for ?SCA Il-2 and III-1 only O |-1 and l-3 only O |-1, 1-2, II-2 and III-1 only |-1 and l-2 only O II-1only O 1-1, 1-2, I-3, Il-2 and IlI-1 محو التحديد --A RFLP is discovered that is linked to the gene for Duchenne’s muscular dystrophy (DMD). DMD is an X-linked, recessive trait. The RFLP is 2 map units from the gene for DMD. Consider the following pedigree and Southern blot using a probe that hybridizes to the RFLP. Which band/s is/are associated with DMD? What is the genotype for individuals 3 and 4? (Remember, this is an X linked disease, so use X’s and Y’s to denote). Individual 9 married a man who does NOT have muscular dystrophy, and she is pregnant. DMD is an X-linked trait. What is the probability for their child to have DMD? An amniocentesis is performed and it is determined that 9’s child in utero has only a 10 kb band that hybridizes to the same probe used above. What can you say about the child now?The pedigree below shows the phenotypes of the ABO blood groups and Rhesus factors [positive (+) and negative (-)] for several members of a family. I (B+ AB- 1 2 3 4 II O- A+ В- B- AB+ A+ 1 2 4 5 6 a. What are the ABO blood group genotypes of individuals I-1 and I-2? b. Which child/ren of individual I-4 can donate blood to him? c. Which individual in the pedigree can donate blood to all the other individuals in the pedigree?
- y 301 Amelogenesis imperfecta is X-linked dominant. Affected XY individuals have extremely thin enamel on the teeth while XX carriers have grooved teeth from uneven deposition of enamel. If an unaffected XY individual were to produce children with a XX carrier partner, a. what would be the expected chance of a XY child being affected with the disease? b. what would be the expected chance of a XY child being affected with the disease?There are six types of agglutinogen named C,D, E and c,d,e.the first three are dominant and last three are recessive.discussConsider the pedigree below of a dominant autosomal trait. Which individual must be non-penetrant? Select all that apply. I-1 T-2 I-1I-2 13 I-4 II-5 III-3 IV-1 IV-2 IV-3 III-2 1-2 Il-5 IIl-1 [V-2 IV-1. IV-3 Il-4