Mr PEPE, a 23 year old University drop out, ingests nine tablets of paracetamol to commitsuicide. He is brought to a clinic without any manifestations of the overdose.Discuss measures that could be applied to minimize the absorption of the overdose ofparacetamolMr PEPE, a 33 year old farmer, takes a drug which has a Therapeutic Index of less than 1 foran undisclosed heart disease. He is diagnosed with anaphylaxis probably resulting from thedrug. The anaphylaxis is being treated with IM adrenalineA. Define Therapeutic indexB. What is the significance of the drug having a Therapeutic Index of less thanC. Describe the drug antagonism involved in the above case

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PE, a 23 year old University drop out, ingests nine tablets of paracetamol to commit suicide. He is brought to a clinic without any manifestations of the overdose. Discuss measures that could be applied to minimize the absorption of the overdose of paracetamol

PE, a 23 year old University drop out, ingests nine tablets of paracetamol to commit suicide. He is brought to a clinic without any manifestations of the overdose. Discuss measures that could be applied to minimize the absorption of the overdose of paracetamol

Principles Of Pharmacology Med Assist

6th Edition

ISBN:9781337512442

Author:RICE

Publisher:RICE

Chapter7: Drug Sources, Schedules, And Dosages

Section: Chapter Questions

Problem 18RQ

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Question

Mr PEPE, a 23 year old University drop out, ingests nine tablets of paracetamol to commit
suicide. He is brought to a clinic without any manifestations of the overdose.
Discuss measures that could be applied to minimize the absorption of the overdose of
paracetamol
Mr PEPE, a 33 year old farmer, takes a drug which has a Therapeutic Index of less than 1 for
an undisclosed heart disease. He is diagnosed with anaphylaxis probably resulting from the
drug. The anaphylaxis is being treated with IM adrenaline
A. Define Therapeutic index
B. What is the significance of the drug having a Therapeutic Index of less than
C. Describe the drug antagonism involved in the above case

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a 49yrs old man is refered for an-ongoing care after having suffered an Acute Myocardial Infarction. The results from the cardiologist states the patient is apparently not hypercholesterolaemic but is somewhat obese and his father died of a ‘’heart attack’’ at 59yrs of age. On clinical examination you confirmed the obesity (BMI- 31), the patient’s Bp is 165/105mmHg, he admits to smoking 20-30 cigarette a day until his AMI, but no overt evidence of hyperlipidaemia is detected. Other than his father, there is no clear history of premature Coronary Arthery Disease (CAD) in his family. His Total fasting Cholesterol is 5.2mmol/L, HDL- Cholesterol- 0.8 mmol/L, triglycerides- 2.7mmol/L Reference Total Cholesterol (3.10- 6.50mmol/L) HDL- Cholesterol (1.03- 1.55mmol/L) Triglycerides (0.3-1.70 mmol/L) LDL- Cholesterol (2.60- 4.90mmol/L) Discuss the lipid profile in terms of its risk potential and causation Discuss the overall risk of the patient what other laboratory…