Pathways to cell death in ischaemia  There are many overlapping and interacting events and pathways involved in ischaemic injury in the brain.  Create your own “vision/map” of these pathways and how they interact  Diagram - pictures  Flowchart  A combination You should consider including  The initial event  Cellular energy failure  Excitotoxicity  Ca2+ overload  Oxidative stress  Inflammation  Apoptosis & necrosis  Reperfusion injury

Principles Of Pharmacology Med Assist
6th Edition
ISBN:9781337512442
Author:RICE
Publisher:RICE
Chapter8: Forms Of Drugs And How They Act
Section: Chapter Questions
Problem 29RQ
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Pathways to cell death in ischaemia

 There are many overlapping and interacting events and pathways involved in ischaemic injury in the brain.

 Create your own “vision/map” of these pathways and how they interact

 Diagram - pictures  Flowchart
 A combination

You should consider including

 The initial event
 Cellular energy failure
 Excitotoxicity

 Ca2+ overload
 Oxidative stress
 Inflammation
 Apoptosis & necrosis  Reperfusion injury

 

 

 

Points for therapeutic intervention

 Looking at the diagrams of events in the ischaemic cascade – identify at least 3 points at which you could potentially interact with this cascade with a drug- based therapeutic.

Indicate with what the drug would interact (enzyme, channel, receptor, transporter etc)

And what kind of action you would expect it to have.

Why would you expect this target might be useful in preventing downstream damage for stroke patients?

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