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Parkinson's Disease results in a(n) (increase or decrease) in D1 mediated effects on striatal medium spiny neurons. This results in excess (inhibition or excitation) of the thalamus and cortex.
Parkinson's disease is a neurological movement disorder that occurs due to some neurons in the brain are gradually break down or dies. As these neurons produce a chemical messenger in the brain called dopamine and when these neurons are damaged or lost then dopamine levels decreases that will produce abnormal activity in the brain. This in turn leads to impaired movement, tremor in just one hand, stiffness or slowing of movement, impaired posture, and balance problems, loss of automatic movements, speech become soft or slurred, and also changes in writing.
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