Parkinson’s disease is a devastating, progressive disorder ofthe central nervous system. Damage to dopaminergic nervetracts in the brain causes tremors and impaired musclecoordination. An early-onset (inherited) form of the diseasehas been linked to a defective protein, now called parkin.Parkin has E3 activity. Describe, in general terms, howneurons with this defective protein are damaged.

Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
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Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...
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Parkinson’s disease is a devastating, progressive disorder of
the central nervous system. Damage to dopaminergic nerve
tracts in the brain causes tremors and impaired muscle
coordination. An early-onset (inherited) form of the disease
has been linked to a defective protein, now called parkin.
Parkin has E3 activity. Describe, in general terms, how
neurons with this defective protein are damaged.

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