If the frequency of those homozygous for a rare clinically relevant allele that causes an autosomal monogenic recessive condition in a given population of 15 million individuals is 1/8500, how many individuals are likely to be carriers of the causative mutation?

Q: We often speak of diseases such as phenylketonuria (PKU) andachondroplasia as having a genetic…

A: When the disorder is caused by the mutation in a gene or multiple gene or by combination of the gene…

Q: Phenylketonuria (PKU) is a disorder caused by a recessive allele. Two carrier individuals have…

A: When the gene aur phenylalanine hydroxylase is defective due to mutation in Its gene on chromosome…

Q: Why are genetic variants with large effects on traits generally rarer than those with smaller…

A: Genetic variants with large effects on traits are often rarer because they are subject to stronger…

Q: How we can know the rare inherited genetic disorders by the incidence ? Explain

A: Inheritance is the process of transmitting the traits from parent to offspring. Traits of an…

Q: Circle all inheritance patterns that you cannot rule out to explain this pedigree. individuals…

A: A pedigree chart illustrates a family's genetic history in graphical form by demonstrating the…

Q: Galactosemia is an autosomal recessive human disease that is treatable by restricting lactose and…

A: Let,  G - allele for normal galactosemia gene g - allele for recessive galactosemia allele.  Since,…

Q: Glucose-6-phosphate dehydrogenase (G6PD)-deficiency is another human red blood cell disease that…

A: The alleles are the alternative forms of a gene that are located on the same locus of a homologous…

Q: What is the pattern of inheritance? Please Provide a specific reason that justifies your selection…

A: Pattern of anheritance could be autosomal or sex linked..Autosomal   inheritance means that the…

Q: ake the example of B-thalassemia, an autosomal recessive genetic disease that particularly affects…

A: A point mutation is a change in the single nucleotide pair of DNA.

Q: What is the probability that their firstborn child will be inartistic, immoral and greedy? What is…

A:

Q: Sickle cell anemia is a genetically inherited autosomal recessive trait in which results in a…

A: According to Hardy Weinberg`s equilibrium p2 + q2 +2pq =1 and p+q=1 p = frequency of the dominant…

Q: Marfan syndrome is a disease caused by a rare dominant allele of the fibrillin-1 gene. Fibrillin-1…

A: Marfan syndrome refers to the genetic disorder related to connective tissue characterized by tall…

Q: In a family-based genetic study for a mental disorder called marijuana dependence, a total of 50…

A: Marijuana is widely used throughout the world. It is seen that about 50–70% of the liability to…

Q: Below is a pedigree of a human blinding disease. Use this pedigree to answer the following…

A: Pedigrees help in visualizing the inheritance patterns of specific genetic traits or diseases within…

Q: Give nine examples of lethal alleles in humans, other animals, and plants and a brief molecular…

A: Lethal alleles are those that cause an organism's death when they are present; they can be inherited…

Q: A male dog is a carrier for the autosomal recessive disorders centronuclear myopathy (Y/y) and von…

A: Centronuclear myopathy and von Willebrand disease is an autosomal dominant disease and is a single…

Q: Explain why most loss-of-function alleles (hypomorphic or amorphic) are recessive to wild-type…

A: Recessive mutations inactive the affected gene and lead to loss- of -function.recessive mutations…

Q: The p value resulting from a Chi squared test tells you a)Mendel's ratios. b)how many degrees of…

A: A Chi-square test is a way of quantifying the various deviations expected by chance if a hypothesis…

Q: Achondroplasia is a hereditary disease with a very characteristic phenotypic manifestation. The…

A: Introduction  The Hardy-Weinberg principle, also known as the Hardy-Weinberg equilibrium, model,…

Q: Identify each of the following as an example of allele, genotype, and/or phenotype frequency: A.…

A: Allele frequency is defined as the number of individual alleles of a certain type divided by the…

Q: Two different variants (alleles) of ß-globin are found in African populations that offer some…

A: Hardy Weinberg’s principle is the mathematical representation of population analysis which…

Q: In pedigrees, individuals are usually specified by using a Roman numeral for their generation in the…

A: Cystic fibrosis (CF) is an inherited disorder that causes severe damage to the lungs, digestive…

Q: Consider the MN blood system in humans. This blood system consists of only two alleles, M and N, and…

A: A population is a group of individuals of the same species inhabiting a specific geographical area.…

Q: Phenylketonuria (PKU) is caused by the absence of the enzyme phenylalanine hydroxylase, which…

A: Phenylketonuria (PKU) : Phenylketonuria (PKU) is an inherited metabolic disorder that affects the…

Q: If the frequency of those homozygous for a specific mutation that causes an autosomal monogenic…

A: ...

Q: The pedigree below shows the inheritance of a disease that is caused by a late onset, dominant,…

A: Late onset meaning pathological conditions whose signs and symptoms manifest late in the life of an…

Q: Galactosemia is a metabolic condition, caused by a recessive allele, which prevents affected…

A: Galactosemia is a disorder of the metabolism of sugar that affects the body processes and metabolism…

Q: A recessive maternal effect mutant in zebrafish, called ichabod, results in embryos lacking heads…

A: The correct answer is option C.

Q: A biotechnology company offers a direct-to-consumer test called the Carrier Status report that…

A: Genetic testing or DNA testing is done to identify errors or changes occurred in a DNA sequence or…

Q: 1. Draw the pedigree for Amita's family and determine the mode of inheritance if any. 2. Explain how…

A: From the given data, it is clear that the disease is autosomal, not sex-linked. As if it was…

Q: Following the analysis of a pedigree, a genetic link at 4cM is considered between a mutation leading…

A: In this question, we are presented with information about a pedigree analysis and the probabilities…

Q: Until very recently, the fitness of an individual getting familial retinoblastoma was zero, and if…

A: Fitness is the propensity of an individual to reproduce and contribute its genes to the progeny. A…

Q: Phenylketonuria (PKU) is caused by the absence of the enzyme phenylalanine hydroxylase, which…

A: Phenylketonuria (PKU) is a genetic condition caused by a lack of the enzyme phenylalanine…

Q: How would present allele frequencies of the sickle cell allele change, if there was no heterozygote…

A: Sickle cell anemia/SCA is an inherited-hematological disorder that significantly affects the shape…

Q: None

A: Important information: Retinoblastoma (Rb) A type of cancer that develops in the retina, primarily…

Inheritance and Mendelian Genetics

Inheritance means the passing of traits to offspring from parents. These traits could be passed either through asexual reproduction or sexual reproduction. The offspring receives the genetic material from the parents. Mendelian inheritance is a certain biological inheritance that follows the rules and principles laid down by Gregor Mendel in 1865. The initial hypothesis was considered wrong, but other inheritance theories modified the concept of inheritance and thus genetics.