If the frequency of those homozygous for a rare clinically relevant allele that causes an autosomal monogenic recessive condition in a given population of 15 million individuals is 1/8500, how many individuals are likely to be carriers of the causative mutation?

Phenylketonuria is one of the most common recessive genetic disorders in humans. Infants with PKU are missing an enzyme called phenylalanine hydroxylase, needed to break down an amino acid called phenylalanine. If a strict diet that minimizes the amount of phenylalanine in the diet is not followed, a severe nervous disorder may result. If two heterozygous parents have a child, hah is the possible genotype and phenotype for this individual?

Tay–Sachs disease is caused by loss-of-function mutations ina gene on chromosome 15 that encodes a lysosomal enzyme.Tay–Sachs is inherited as an autosomal recessive condition.Among Ashkenazi Jews of Central European ancestry, about1 in 3600 children is born with the disease. What fraction ofthe individuals in this population are carriers?

In humans the allele coding for normal metabolism of the amino acid phenylalanine (P) is dominant   over the recessive autosomal allele (p) that causes the disease phenylketonuria, or PKU.  Without   treatment, this disease is characterized by brain damage due to the failure of the gene to code correctly     for the enzyme phenylalanine hydroxylase.  If a man marries a woman and both are heterozygous for     hemophilia and heterozygous for PKU, what is the chance that they will have a child afflicted by     both diseases? Your response MUST include:(a): list the traits involved (example: Color: Blue- B (dominate) Green - b (recessive) -Do not use this example as this is not part of the problem(b): identify if its a monohybrid or dihybrid cross and why (use prompt above) (c): create a punnet square that represents the problem above

Cystic fibrosis (CF) is an autosomal recessive trait. A three-generation pedigree is shown below for a family that carries the mutant allele for cystic fibrosis. Note that carriers are not colored in to allow you to figure out their genotypes.      Normal allele =  F      CF mutant allele =  f        What is the genotype of individual #13? A) ff B) FF C) Ff  D) it is impossible to tell

A worldwide survey of genetic variation in human populations reported the autosomal codominant MN blood group types in a sample of 1029 Chinese individuals from Hong Kong. The sample contained 342 people with blood type M, 500 with blood type MN, and 187 with blood type N. Part A The number of people expected in each blood-type category is: Enter the values expected for MM, MN and NN blood-type categories, respectively, separated by commas and using two decimal places (example 1.02, 2.30, 3.45).

Tay-Sachs disease is a rare human disease in which toxic substances accumulate in nerve cells. The recessive allele responsible for the disease is inherited in a simple Mendelian manner. For unknown reasons, the allele is more common in populations of Ashkenazi Jews of eastern Europe. A woman is planning to marry her first cousin, but the couple discovers that their shared grandfather’s sister died in infancy of Tay-Sachs disease.a. Draw the relevant parts of the pedigree, and show all the genotypes as completely as possible. b. What is the probability that the cousins’ first child will have Tay-Sachs disease, assuming that all people who marry into the family are homozygous normal?

There are two genetic disorders that result from mutation in imprinted genes: Prader-Willi syndrome, Angelman syndrome.  Angelman syndrome results from deletion of UBE3A, which is a gene imprinted such that only the maternal copy is expressed. In the pedigree above, individual I-1 is heterozygous for a deletion of UBE3A and does not have Angelman syndrome.  Individual I-2 is homozygous wild type for UBE3A.  Which individuals in the pedigree are at risk for exhibiting Angelman syndrome, if any?  (Who could potentially have the syndrome, based on what alleles it is possible for them to inherit and express?)   Question 8 options:   Only I-1 could have been at risk.  If he does not have the syndrome, no one in the pedigree could.   Only III-1 is at risk   I-1, II-2, and III-1 are all at risk   Only II-2 is at risk   No one in the pedigree is at risk   Both II-2 and III-1 are at…

A rare blinding disease that has a relation to dengenerative factors is partially penetrant. In the following pedigrees for two families, the affected symptomatic individuals (black circles and squares) have been diagnosed with this disease due to the mutation in mitochondrial DNA m.14484T>C.     If III.4 is homoplasmic for m.14484T>C in hair, blood, urine and other tissues examined. What will occur with IV.7 then?

Sickle cell anemia is a genetically inherited autosomal recessive trait in which results in a condition that there are not enough healthy red blood cells to carry oxygen throughout the body due to the production of red blood cells that are sickle shaped. The frequency of the sickle cell condition is as high as 10% in Central Africa compared to 0.5% in the United States. Malaria is a disease caused by a parasite that infects healthy red blood cells and can lead to death. However, the parasite is not able to infect sickle cell red blood cells. Scientists claim that the higher frequency of sickle cell carriers is due to the presence of malaria. Provide reasoning to support the claim.