One form of familial hypercholesterolemia (FH) shows incomplete dominance.  Homozygous dominant individuals (HH) have normal cholesterol, heterozygous individuals have mildly elevated cholesterol and homozygous recessive individuals (hh) have severe FH.    If a woman with mild disease marries a man with no FH, what percent of their children will have severe FH? What percent will have mild FH? What percent will be normal?        A man with severe FH has three children with a woman who does not have the condition at all. What are the phenotypic ratios of the offspring?

Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
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Chapter1: The Human Body: An Orientation
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One form of familial hypercholesterolemia (FH) shows incomplete dominance.  Homozygous dominant individuals (HH) have normal cholesterol, heterozygous individuals have mildly elevated cholesterol and homozygous recessive individuals (hh) have severe FH.  

  •  If a woman with mild disease marries a man with no FH, what percent of their children will have severe FH? What percent will have mild FH? What percent will be normal?       
  • A man with severe FH has three children with a woman who does not have the condition at all. What are the phenotypic ratios of the offspring?

 

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