Navigate to the National Library of Medicine Book on Genes and Disease. This book shows all of the human chromosomes. When you click on any of the chromosomes in the karyogram or on the right hand menu, you will find more information on the chromosome. Click on one of the chromosomes. Select a disease that has been mapped to that chromosome. Choose one that you have not heard about. Fill in the following table. Repeat with another chromosome. Note: not all diseases are listed on the cytogenetic maps. Searching the internet may come up with a disease that is not listed. Please follow the instructions for full marks. (5 marks) Chromosome Number. Chromosome Number # of genes # base pairs Disease name Brief summary of the disease (don't just copy and paste)

Chorionic villus sampling is a procedure to determine if there are any abnormalities in chromosome number in the fetus. Why can the chorionic villi be used to determine abnormalities in the fetus?

A defective gene on chromosome 15 causes Tay-Sachs disease. It is a central nervous system neurodegenerative disease that most often affects infants, though older children and adults can have late-onset forms of the disease. The defective gene prevents the body from making a protein called hexosaminidase A. Without, hexosaminidase A, chemicals called gangliosides build up in the nerve cells of the brain, destroying brain cells.A couple has one daughter with Tay-Sachs disease and three other unaffected children. Neither the mother, nor father, nor any of the biological grandparents of the affected daughter have had the disease. Tay-Sachs disease most likely demonstrates what type of inheritance? Select one: a. autosomal dominant b. X-linked recessive c. X-linked dominant d. autosomal recessive

Which of the following individuals would you expect to share 25% of their DNA with you? Select all correct answers. Your aunt or uncle Your child Your first cousin Your grandparent Your parent Your sibling