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Native chemical ligation works by sequential nucleophilic acyl substitution reactions, but the mechanism depicting this in Figure 1 is not correct. Using your knowledge of nucleophilic acyl substitution, redraw the mechanism in Figure 1 so that it is chemically correct. Make sure to depict all of the tetrahedral intermediates and proton transfer

Native chemical ligation works by sequential nucleophilic acyl substitution reactions, but the mechanism depicting this in Figure 1 is not correct. Using your knowledge of nucleophilic acyl substitution, redraw the mechanism in Figure 1 so that it is chemically correct. Make sure to depict all of the tetrahedral intermediates and proton transfer

Chemistry
Chemistry
10th Edition
ISBN:9781305957404
Author:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Publisher:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Chapter1: Chemical Foundations
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Problem 1RQ: Define and explain the differences between the following terms. a. law and theory b. theory and...
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Native chemical ligation works by sequential nucleophilic acyl substitution reactions, but the mechanism depicting this in Figure 1 is not correct. Using your knowledge of nucleophilic acyl substitution, redraw the mechanism in Figure 1 so that it is chemically correct. Make sure to depict all of the tetrahedral intermediates and proton transfer
Peptide-1 FCSR NH;CH-C- NH;CH-C Peptide-2 Chemoselective reaction NH Peptide-1 ÇH-C-Peptide-2 Spontaneous rearrangement Poplide- -C-NH-CH-C- Peptide-2 SH
Transcribed Image Text:Peptide-1 FCSR NH;CH-C- NH;CH-C Peptide-2 Chemoselective reaction NH Peptide-1 ÇH-C-Peptide-2 Spontaneous rearrangement Poplide- -C-NH-CH-C- Peptide-2 SH
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