Individuals who possess a C allele at the R$429358 SNP, located in the 4th Exon of the ApoE gene, are more likely to have a variant at the ApoE protein that can increase the risk of Alzheimer's disease over a T allele. You are running a set of samples on a SNP chip and determine that your population has 2 CC individuals, 16 CT individuals, and 32 TT individuals. The C and T alleles in the ApoE gene are segregating at the frequencies observed in the 1st generation you observe the population. If you assume a standard Wright-Fisher model of genetic drift, what is the expected probability of eventual fixation of the T allele? Is this a certain outcome?

Human Anatomy & Physiology (11th Edition)
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Chapter1: The Human Body: An Orientation
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Individuals who possess a C allele at the Rs429358 SNP, located in the 4th Exon of the ApoE gene, are more likely to have a variant at the ApOE protein
that can increase the risk of Alzheimer's disease over a T allele. You are running a set of samples on a SNP chip and determine that your population has 2
C individuals, 16 CT individuals, and 32 TT individuals.
The C and T alleles in the ApoE gene are segregating at the frequencies observed in the 1st generation you observe the population. If you assume a
standard Wright-Fisher model of genetic dnit, what is tho expocted probabilily of eventual fixation of the T allele? is this a certain outcome?
Transcribed Image Text:Individuals who possess a C allele at the Rs429358 SNP, located in the 4th Exon of the ApoE gene, are more likely to have a variant at the ApOE protein that can increase the risk of Alzheimer's disease over a T allele. You are running a set of samples on a SNP chip and determine that your population has 2 C individuals, 16 CT individuals, and 32 TT individuals. The C and T alleles in the ApoE gene are segregating at the frequencies observed in the 1st generation you observe the population. If you assume a standard Wright-Fisher model of genetic dnit, what is tho expocted probabilily of eventual fixation of the T allele? is this a certain outcome?
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