
Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN: 9780134580999
Author: Elaine N. Marieb, Katja N. Hoehn
Publisher: PEARSON
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In the science research article "Maternal alloantigens promote the development of tolerogenic fetal regulatory t cells in utero" what are some important annotations and key findings important to note?
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- What is the role of histocompatibility antigens in humans and where are they located?arrow_forwardCreate a full analysis of the article: Maternal alloantigens promote the development of tolerogenic fetal regulatory T cells in utero, highlighting all necassary information, about ethics, findings, and collaborative scientific knowledge, in depth as possible?arrow_forwardChimeric Antigen Receptor T cells (CAR T cells): Question 26 options: Are typically used to study how drugs are metabolized. Are very potent against solid tumors but do not work well against blood cancers (e.g., leukemias). Are derived from the blastocyst then developed into modified T cells Are potent against some blood cancers (e.g., leukemias) but have serious side effects. involves mutating specific amino acid residues to tryptophan, alanine, and prolinearrow_forward
- For the following mechanism that is thought to contribute to maternal–fetal tolerance, state whether you would consider it to be an example of T cell tolerization, control of responses by regulatory lymphocytes, immune deviation or immune privilege: a) Tissues at the maternal–fetal interface are populated with non-professional APCs that lack costimulatory moleculesarrow_forwardTrue / False: Affinity maturation is the process by which the affinity of BCRs and TCRs produced in response to antigen increases with prolonged orrepeated exposure to that antigen. True / False: TLRs are only expressed on the cell surface, and function to detect PAMPS and DAMPS. True / False: T cells undergo positive, but not negative, selection during cellular development. True / False: The Fc portion of antibodies consist exclusively of the heavy chain. True / False: ADCC relies on the activity of mostly basophils or mast cells.arrow_forwardIn a specific type of tumor, cytotoxic T cells can recognize but not kill the tumor cell. Interaction of PD-L1 in tumor cells with PD1 in cytotoxic T cells plays a role in shaping the immune response by initiating signal transduction cascades in both cell types. What will happen if the signal transduction cascade in cytotoxic T cells is blocked? T cells will be activated and kill tumor cells T cells can recognize the cancer cells but will not be activated Tumor cell will undergo programmed cell deatharrow_forward
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