In the following pedigree of an autosomal recessive disorder, what is the probability that IV-1 will be affected? I II III IV 1/2 1/12 3/4 2/3 O 1/4 Rr 1 R 2 Rr 2 R 3 RR 3 R 1 5 Rr 4 2

Below is a pedigree chart for a family that has a history of Alkaptonuria.   Individuals infected with this condition can have darkened skin, brown urine, and can suffer from joint damage and other complications.  Given this pedigree answer the following questions.   Given the data in the pedigree chart is this genetic condition autosomal dominant or autosomal recessive? What are the genotypes for #1, #2, and #3?  If either of the 4th generation "aa" females were to mate with a homozygous dominant male would any of their offspring illustrate the phenotype?  Why or why not?

A woman is color blind (an X-linked, recessive trait).  What are the chances that her sons will be color blind? Show a punnet square

What is the most likely mode of inheritance for the disease depicted in the following pedigree? I II III 1 1 2 1 2 autosomal recessive autosomal dominant 3 3 2 4 4 5 5 6

What is the inheritance pattern shown in the following pedigree? O mitochondrial O Autosomal recessive O X-linked recessive O X-linked dominant O y linked O Autosomal dominant

The following pedigree is for a disease that is completely penetrant. For this question,do not make any assumptions of whether the disease is rare or common in the general population. Khich ƠNE of these modes is NOT possible? T O autosomal dominant X-linked dominant O autosomal recessive O X-linked recessive

70 T 꿈 ㅁ ㅁ 이어어어어어어 In the pedigree shown, indicate whether each of the following inheritance patterns is possible by selecting YES or NO from the appropriate drop down menu. Y-linked Autosomal Recessive Autosomal Dominant X-linked Recessive X-linked Dominant ()

1. The pedigree chart in Figure 5.29 shows the inheritance of haemopiu family. Study the pattern of inheritance in the pedigree chart, and then answer the questions that follow. о 5 6. 3 8 9 10 11 Key Unaffected male Haemophiliac male О Unaffected female Fig. 5.29 Pedigree chart of a family affected by haemophilia a) What is the genotype and phenotype of individuals 2 and 4? b) (i) How many of the unaffected family members are definitely carriers of the recessive allele? (ii) How are you able to tell which of the family members are carriers? (4) (1) (3) c) (i) If Individual 11 marries a carrier female, what percentage of their sons is likely to be haemophiliacs? (1) (ii) Use a genetic diagram to show how you worked out your answer in i, (6) 2. Why is haemophilia never passed from father to son, even though it is most common in males? (4) 3. Can a mother pass on a sex-linked gene to her daughter? (1) 4. Sipho has red-green colour blindness. One of his grandfathers was also. colour…

In a parental cross for an autosomal MOI, the ratio (Disease phenotype):(WT phenotype) differ for the scenarios: (i) the father is affected and mother is unaffected; and (ii) the mother is affected and the father is unaffected.  a) true  b) false

Could this be an autosomal dominant trait? C O yes O no Could this be an autosomal dominant trait? OO O no yes