In considering the formation of the A–P and D–V axes in Drosophila, we noted that, for mutations such as bcd, homozygous mutant mothers uniformly produce mutant offspring with segmentation defects. This outcome is always true regardless of whether the offspring themselves are bcd+/bcd or bcd/bcd. Some other maternaleffect lethal mutations are different, in that the mutant phenotype can be “rescued” by introducing a wild-type allele of the gene from the father. In other words, for such rescuable maternal-effect lethals, mut+/mut animals are normal, whereas mut/mut animals have the mutant defect. Explain the difference between rescuable and nonrescuable maternal-effect lethal mutations.

Human Anatomy & Physiology (11th Edition)
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ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
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In considering the formation of the A–P and D–V axes in
Drosophila, we noted that, for mutations such as bcd,
homozygous mutant mothers uniformly produce mutant offspring with segmentation defects. This outcome
is always true regardless of whether the offspring themselves are bcd+/bcd or bcd/bcd. Some other maternaleffect lethal mutations are different, in that the mutant
phenotype can be “rescued” by introducing a wild-type
allele of the gene from the father. In other words, for
such rescuable maternal-effect lethals, mut+/mut animals are normal, whereas mut/mut animals have the mutant defect. Explain the difference between rescuable
and nonrescuable maternal-effect lethal mutations.

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