True or false about the following statements on Drosophila eye development a. Hh, which is expressed by the developing photoreceptors in the posterior eye disc, induces cells in the morphogenetic furrow (MF) to express DPP, which is the ligand of DPP (BMP) signaling. b. Wg inhibits while Hh and DPP promote the expression of Eya in the preproneural (PPN) domain anterior to the MF, which is essential for the induction of photoreceptor differentiation and movement of MF from posterior to anterior. c. Eya (Eyes absent), sine oculis (so), Ey (Eyeless), and Eyg (Eygone) are the retinal determination (RD) network genes required for retinal determination and induction of atonal expression.
True or false about the following statements on Drosophila eye development
a. Hh, which is expressed by the developing photoreceptors in the posterior eye disc, induces cells in the morphogenetic furrow (MF) to express DPP, which is the ligand of DPP (BMP) signaling.
b. Wg inhibits while Hh and DPP promote the expression of Eya in the preproneural (PPN) domain anterior to the MF, which is essential for the induction of photoreceptor differentiation and movement of MF from posterior to anterior.
c. Eya (Eyes absent), sine oculis (so), Ey (Eyeless), and Eyg (Eygone) are the retinal determination (RD) network genes required for retinal determination and induction of atonal expression.
d. EGFR signaling is required for the differentiation of all the photoreceptor neurons. In addition EGFR signaling is also required for maintaining cell survival in posterior eye discs.
e. During Drosophila eye development, cell proliferation in the second mitotic wave is required to provide sufficient undifferentiated cells surrounding the differentiating photoreceptors for the stepwise recruitment of additional cell types into the developing ommatidia.
f. Eyeless and Eyegone have similar structure and function as the mammalian Pax6 protein. Loss of function mutations of either ey or eyg cause loss of eye tissues and ectopic expression of either gene in wing discs will induce ectopic eye formation.
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