
Biochemistry
9th Edition
ISBN: 9781319114671
Author: Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher: W. H. Freeman
expand_more
expand_more
format_list_bulleted
Question
In 1965, Monod, Wyman and Changeux put forward the MWC model for cooperative binding of
ligands to oligomeric proteins, which also produced the MWC equation above. Give a detailed
discussion on this model under the following points:
Hoe die MWC model koöperatiwiteit verklaar. / How the MWC model accounts for
cooperative effects.
Wat die effek van allosteriese reguleerders sal wees op die algehele bindingskurwe. / What
the effect of allosteric regulators will be on the overall binding curve.
Hoe K-reeks en V-reeks ensieme beïnvloed word deur reguleerders. / How K-series and Vseries
enzymes are affected by modifiers.
Expert Solution

This question has been solved!
Explore an expertly crafted, step-by-step solution for a thorough understanding of key concepts.
This is a popular solution
Trending nowThis is a popular solution!
Step by stepSolved in 3 steps

Knowledge Booster
Similar questions
- Cholera is an acute, diarrheal disease caused by infection of the intestine with the gram-negative, motile bacterium Vibrio cholerae. After colonizing the small intestine, V. cholerae secretes cholera toxin (CTX), a protein that ribosylates the Gsa subunit of a G protein, thereby inhibiting its GTPase activity. This causes the dysregulation of a cellular chloride ion channel, resulting in efflux of ions and water from the infected enterocytes into the intestinal lumen. Studies have implicated sodium bioenergetics in the pathogenesis of V. cholerae in humans. An electrochemical gradient of Na+ known as the "sodium motive force" provides V. cholerae with the energy for key functions. The gradient is predominantly established by the Nat-pumping NADH:quinone oxidoreductase (Na-NQR) enzyme. Na+-NQR is a multi-substrate enzyme comprised of six distinct subunits designated A-F (Table 1) that are encoded within the same operon. In a process similar to proton pumping by Complex I of the…arrow_forwardG protein-coupled receptors: O have enzymatic activity O have guanosine nucleotide exchange activity O open ion channels O activate enzymes O have seven transmembrane domains 1 ◄ Previous No new data to save. Last checked at 7:arrow_forward3 of 16 Which statement about the IP3 DAG pathway is false? O Diacylglycerol can act as a second messenger. Inositol trisphosphate can act as a second messenger. O Protein kinase C can phosphorylate a wide variety of proteins. O Inositol trisphosphate remains bound to the membrane after phospholipase C catalyzes its formation. Inositol trisphosphate can open ion channels in the membraņes of smooth endoplasmic reticulum, releasing calcium into the cytoplasm.arrow_forward
- What is cooperative binding and how can I distinguish positive and negative cooperativity? How does cooperativity amplify the effects of a regulatory molecule?arrow_forwardDraw a picture showing how serotonin could bind to a protein. Include at least 2 different types of interactions and label the types of stabilizing interactions. (serotonin attached)arrow_forwardDraw a diagram of a membrane receptor and include the following details. Include a depiction of the plasma membrane with which it is associated; label the locations of the extracellular space, the cytoplasm, and the ligand-binding domain.arrow_forward
- Pathway divergence occurs when: signaling pathways use a common intermediate one signaling pathway triggers another O signaling pathways produce the same outcome signaling pathways split to produce multiple outcomes Question 8 Where are receptor tyrosine kinases usually phosphorylated? O tyrosine residues in the allosteric regulatory portion tyrosine residues in the N-terminal portion tyrosine residues in the transmembrane portion O tyrosine residues in the C-terminal portionarrow_forwardFollowing the production of membrane extracts using the non-ionic detergent Triton X-100, you analyze the membrane lysates via mass spectrometry and note a high content of cholesterol and sphingolipids. Furthermore, biochemical analysis of the lysates reveals potential kinase activity. What have you probably isolated?arrow_forwardContinuous exposure of a G protein-coupled receptor to its ligand leads to a phenomenon known as desensitization. Describe several molecule mechanisms for receptor desensitizationarrow_forward
- Cyclic AMP (CAMP) is an important signaling molecule in cells. The synthesis and degradation of CAMP is diagrammed in the following figure: ATP ©2017 Pearson Education, Inc. 12pt Adenylyl cyclase Edit View Insert Format Tools Table Paragraph Pyrophosphate 3'c- P-P₁ 5'C BI Both caffeine (coffee, cola) and theophylline inhibit the enzyme phosphodiesterase that converts CAMP to AMP, allowing cAMP levels to temporarily remain high. Briefly discuss the possible effect of these drugs on the second messenger action of CAMP. What might the effect of caffeine of theophylline be on a signaling pathway? CAMP UA Phosphodiesterase T² H₂O AMP ⠀arrow_forwardDraw a diagram of the "general model" aka “protein-protein interaction model" of suppression to show how it works (or how it can be used to find interacting proteins.)arrow_forwardWhat is the purpose of unfolded protein response? Steps of unfolded protein response that allow toxins to slow down the inactivation of voltage gated sodium channelsarrow_forward
arrow_back_ios
SEE MORE QUESTIONS
arrow_forward_ios
Recommended textbooks for you
- BiochemistryBiochemistryISBN:9781319114671Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.Publisher:W. H. FreemanLehninger Principles of BiochemistryBiochemistryISBN:9781464126116Author:David L. Nelson, Michael M. CoxPublisher:W. H. FreemanFundamentals of Biochemistry: Life at the Molecul...BiochemistryISBN:9781118918401Author:Donald Voet, Judith G. Voet, Charlotte W. PrattPublisher:WILEY
- BiochemistryBiochemistryISBN:9781305961135Author:Mary K. Campbell, Shawn O. Farrell, Owen M. McDougalPublisher:Cengage LearningBiochemistryBiochemistryISBN:9781305577206Author:Reginald H. Garrett, Charles M. GrishamPublisher:Cengage LearningFundamentals of General, Organic, and Biological ...BiochemistryISBN:9780134015187Author:John E. McMurry, David S. Ballantine, Carl A. Hoeger, Virginia E. PetersonPublisher:PEARSON

Biochemistry
Biochemistry
ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:W. H. Freeman

Lehninger Principles of Biochemistry
Biochemistry
ISBN:9781464126116
Author:David L. Nelson, Michael M. Cox
Publisher:W. H. Freeman

Fundamentals of Biochemistry: Life at the Molecul...
Biochemistry
ISBN:9781118918401
Author:Donald Voet, Judith G. Voet, Charlotte W. Pratt
Publisher:WILEY

Biochemistry
Biochemistry
ISBN:9781305961135
Author:Mary K. Campbell, Shawn O. Farrell, Owen M. McDougal
Publisher:Cengage Learning

Biochemistry
Biochemistry
ISBN:9781305577206
Author:Reginald H. Garrett, Charles M. Grisham
Publisher:Cengage Learning

Fundamentals of General, Organic, and Biological ...
Biochemistry
ISBN:9780134015187
Author:John E. McMurry, David S. Ballantine, Carl A. Hoeger, Virginia E. Peterson
Publisher:PEARSON